核糖核酸酶Ⅲ
RNA酶III（Ribonuclease III，簡稱RNase III或RNase C[1]，BRENDA編號：3.1.26.3 （页面存档备份，存于））為一類RNA酶，屬切割雙股RNA的內切酶，均具有RNA酶III結構域[2]。此類RNA酶參與rRNA、SnRNA、SnoRNA與miRNA等RNA的生成過程[3]，可在細胞中的特定位置切割這些RNA的前驅物以產生成熟的RNA[4][5]。三域生物與部分病毒皆具有RNA酶III。
| 核糖核酸酶Ⅲ | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
 RNA酶III與雙股RNA的交互作用 | |||||||||||
| 鑑定 | |||||||||||
| 標誌 | RNA酶III | ||||||||||
| Pfam | PF00636（旧版） | ||||||||||
| InterPro | IPR000999 | ||||||||||
| PROSITE | PDOC00448 | ||||||||||
| SCOP | 1jfz / SUPFAM | ||||||||||
| |||||||||||
RNA酶III可依結構域分為四型[6]。切割miRNA前驅物的Drosha與Dicer分別屬於三型與四型的RNA酶III[7][8]
參考文獻
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- Park, Hongmarn; Yakhnin, Helen; Connolly, Michael; Romeo, Tony; Babitzke, Paul; Gourse, R. L. . Journal of Bacteriology. 15 December 2015, 197 (24): 3751–3759. PMC 4652041 . PMID 26438818. doi:10.1128/JB.00721-15.
- Liang YH, Lavoie M, Comeau MA, Abou Elela S, Ji X. . Mol Cell. 2014, 54 (3): 431–44. PMC 4019767 . PMID 24703949. doi:10.1016/j.molcel.2014.03.006.
- Filippov V, Solovyev V, Filippova M, Gill SS. . Gene. Mar 2000, 245 (1): 213–221. PMID 10713462. doi:10.1016/S0378-1119(99)00571-5.
- Bernstein E, Caudy AA, Hammond SM, Hannon GJ. . Nature. 2001, 409 (6818): 363–6. PMID 11201747. doi:10.1038/35053110.
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