组织蛋白酶L1

组织蛋白酶L1
已知的結構
PDB	人类UniProt搜索: PDBe RCSB
PDBID列表
	1CJL、1CS8、1ICF、1MHW、2NQD、2VHS、2XU1、2XU3、2XU4、2XU5、2YJ2、2YJ8、2YJ9、2YJB、2YJC、3BC3、3H89、3H8B、3H8C、3HHA、3HWN、3IV2、3K24、3KSE、3OF8、3OF9、4AXL、4AXM、5F02、5I4H
識別號
别名	CTSL；, CATL, CTSL1, MEP, cathepsin L
外部ID	OMIM：116880 HomoloGene：129366 GeneCards：CTSL
基因位置（人类）
染色体	9號染色體[1]
终止	87,731,469 bp[1]
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• fibronectin binding; • 半胱氨酸型肽酶活性; • collagen binding; • histone binding; • serpin family protein binding; • 肽酶活性; • 血浆蛋白结合; • cysteine-type endopeptidase activity; • 水解酶活性; • proteoglycan binding; • serine-type endopeptidase activity;
細胞組分	• 細胞外區域; • endolysosome lumen; • lysosomal lumen; • 溶酶体; • 外排體; • 细胞核; • 細胞外空間; • collagen-containing extracellular matrix; • 多囊泡体; • 细胞膜;
生物學過程	• macrophage apoptotic process; • antigen processing and presentation; • adaptive immune response; • antigen processing and presentation of exogenous peptide antigen via MHC class II; • extracellular matrix disassembly; • 蛋白酶解; • toll-like receptor signaling pathway; • cellular response to thyroid hormone stimulus; • collagen catabolic process; • proteolysis involved in cellular protein catabolic process; • regulation of keratinocyte differentiation;
	Sources:Amigo / QuickGO
直系同源
	1514
	无数据
	ENSG00000135047
	无数据
	P07711; Q9HBQ7
	无数据
NM_001257971; NM_001257972; NM_001257973; NM_001912; NM_145918;
	NM_001382757; NM_001382758; NM_001382766; NM_001382767; NM_001382768
	无数据
NP_001244900; NP_001244901; NP_001244902; NP_001903; NP_666023;
	NP_001369686; NP_001369687; NP_001369695; NP_001369696; NP_001369697; NP_001244902.1
	无数据
	維基數據

组织蛋白酶L1（英语：Cathepsin L1）是人类体内由CTSL1基因编码的蛋白质。[3][4][5]该蛋白质是木瓜样蛋白酶，是一种溶酶体半胱氨酸蛋白酶，在细胞内蛋白质分解代谢中起着主要的作用。[6][7][8][9]

作用

组织蛋白酶L1是肽酶C1（组织蛋白酶）MEROPS家族的成员。组织蛋白酶L1在包括正常溶酶体介导的蛋白质周转、抗原、前蛋白加工以及细胞凋亡在内的多种过程中发挥重要的作用。[10]其底物包括胶原蛋白、弹性蛋白和SERPINA1，这是中性粒细胞弹性蛋白酶活性的主要控制元素。组织蛋白酶L1与多种病理过程有关，包括肌病、冠状动脉疾病中的肌原纤维坏死以及肾小管对蛋白尿的反应。它是由二硫键连接的重链和轻链组成的二聚体，均由单一蛋白质前体产生。已发现该基因至少有两种编码相同蛋白质的转录变体。[5]

病毒进入

病毒进入细胞需要2型新冠病毒 S2刺突蛋白的裂解。此过程可以通过位于细胞膜上的蛋白酶——跨膜丝氨酸蛋白酶2或内溶酶体中的组织蛋白酶（主要是组织蛋白酶L1）来完成。[11]羟氯喹可以抑制内溶酶体中组织蛋白酶L1的作用，但由于与跨膜丝氨酸蛋白酶2裂解相比，组织蛋白酶L1的裂解较小，因此羟氯喹对2型新冠病毒感染的抑制作用很小。[11]

炎症

虽然组织蛋白酶L1通常被表征为溶酶体蛋白酶，但它可以被分泌，导致病理性炎症。[12]组织蛋白酶L1和其他木瓜样蛋白酶在引起病理性炎症时往往由巨噬细胞和其他侵入组织的免疫细胞分泌而出。[13]

交互作用

组织蛋白酶L1已被证明与胱抑素A有相互作用。[14][15]

分布

组织蛋白酶L1已在许多生物体中发现，包括鱼类[16]、鸟类、哺乳动物和海绵。[17]

参见

组织蛋白酶V（或称为组织蛋白酶L2或组织蛋白酶U）
组织蛋白酶

参考文献

GRCh38: Ensembl release 89: ENSG00000135047 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
Chauhan SS, Popescu NC, Ray D, Fleischmann R, Gottesman MM, Troen BR. . J Biol Chem. Feb 1993, 268 (2): 1039–45. PMID 8419312. doi:10.1016/S0021-9258(18)54038-2 .
Joseph LJ, Chang LC, Stamenkovich D, Sukhatme VP. . J Clin Invest. Jun 1988, 81 (5): 1621–9. PMC 442598 . PMID 2835398. doi:10.1172/JCI113497.
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Barrett AJ, Buttle DJ, Mason RW. . ISI Atlas of Science. Biochemistry. 1988, 1: 256–260.
Joseph LJ, Chang LC, Stamenkovich D, Sukhatme VP. . The Journal of Clinical Investigation. May 1988, 81 (5): 1621–1629. PMC 442598 . PMID 2835398. doi:10.1172/JCI113497.
Kirschke H, Wikstrom P, Shaw E. . FEBS Letters. February 1988, 228 (1): 128–130. PMID 3342870. doi:10.1016/0014-5793(88)80600-8 .
Dickinson DP. . Critical Reviews in Oral Biology and Medicine. 2002, 13 (3): 238–75. PMID 12090464. doi:10.1177/154411130201300304.
Jackson CB, Farzan M, Chen B, Choe H. . Nature Reviews. Molecular Cell Biology. January 2022, 23 (1): 3–20. PMC 8491763 . PMID 34611326. doi:10.1038/s41580-021-00418-x.
Gomes CP, Fernandes DE, Casimiro F, da Mata GF, Passos MT, Varela P, et al. . Frontiers in Cellular and Infection Microbiology. 2022, 10: 589505. PMC 7753008 . PMID 33364201. doi:10.3389/fcimb.2020.589505 .
Berdowska I, Matusiewicz M. . World Journal of Gastroenterology. October 2021, 27 (39): 6590–6600. PMC 8554394 . PMID 34754154. doi:10.3748/wjg.v27.i39.6590.
Majerle, Andreja; Jerala Roman. . Arch. Biochem. Biophys. Sep 2003, 417 (1): 53–8. ISSN 0003-9861. PMID 12921779. doi:10.1016/S0003-9861(03)00319-9.
Estrada, S; Nycander M; Hill N J; Craven C J; Waltho J P; Björk I. . Biochemistry. May 1998, 37 (20): 7551–60. ISSN 0006-2960. PMID 9585570. doi:10.1021/bi980026r.
Venkatesh K, Prasanth B, Rajesh P, Annie JG, Mukesh P, Jesu A. . Biologia. 2014, 39 (3): 395–406. doi:10.2478/s11756-013-0326-8 .
Sevenich L, Pennacchio LA, Peters C, Reinheckel T. . Biological Chemistry. July 2006, 387 (7): 885–91 [2022-10-31]. PMID 16913838. S2CID 27739485. doi:10.1515/BC.2006.112. （原始内容存档于2022-10-31）.

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外部链接

The MEROPS online database for peptidases and their inhibitors: C01.032
醫學主題詞表（MeSH）：Cathepsin+L

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135047 - Ensembl, May 2017

[2] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8419312-3] Chauhan SS, Popescu NC, Ray D, Fleischmann R, Gottesman MM, Troen BR. . J Biol Chem. Feb 1993, 268 (2): 1039–45. PMID 8419312. doi:10.1016/S0021-9258(18)54038-2 .

[pmid2835398-4] Joseph LJ, Chang LC, Stamenkovich D, Sukhatme VP. . J Clin Invest. Jun 1988, 81 (5): 1621–9. PMC 442598 . PMID 2835398. doi:10.1172/JCI113497.

[entrez-5] .

[6] Barrett AJ, Kirschke H. . Methods in Enzymology. 1981,. 80 Pt C: 535–561. PMID 7043200. doi:10.1016/s0076-6879(81)80043-2.

[7] Barrett AJ, Buttle DJ, Mason RW. . ISI Atlas of Science. Biochemistry. 1988, 1: 256–260.

[8] Joseph LJ, Chang LC, Stamenkovich D, Sukhatme VP. . The Journal of Clinical Investigation. May 1988, 81 (5): 1621–1629. PMC 442598 . PMID 2835398. doi:10.1172/JCI113497.

[9] Kirschke H, Wikstrom P, Shaw E. . FEBS Letters. February 1988, 228 (1): 128–130. PMID 3342870. doi:10.1016/0014-5793(88)80600-8 .

[pmid12090464-10] Dickinson DP. . Critical Reviews in Oral Biology and Medicine. 2002, 13 (3): 238–75. PMID 12090464. doi:10.1177/154411130201300304.

[pmid34611326-11] Jackson CB, Farzan M, Chen B, Choe H. . Nature Reviews. Molecular Cell Biology. January 2022, 23 (1): 3–20. PMC 8491763 . PMID 34611326. doi:10.1038/s41580-021-00418-x.

[pmid33364201-12] Gomes CP, Fernandes DE, Casimiro F, da Mata GF, Passos MT, Varela P, et al. . Frontiers in Cellular and Infection Microbiology. 2022, 10: 589505. PMC 7753008 . PMID 33364201. doi:10.3389/fcimb.2020.589505 .

[pmid34754154-13] Berdowska I, Matusiewicz M. . World Journal of Gastroenterology. October 2021, 27 (39): 6590–6600. PMC 8554394 . PMID 34754154. doi:10.3748/wjg.v27.i39.6590.

[pmid12921779-14] Majerle, Andreja; Jerala Roman. . Arch. Biochem. Biophys. Sep 2003, 417 (1): 53–8. ISSN 0003-9861. PMID 12921779. doi:10.1016/S0003-9861(03)00319-9.

[pmid9585570-15] Estrada, S; Nycander M; Hill N J; Craven C J; Waltho J P; Björk I. . Biochemistry. May 1998, 37 (20): 7551–60. ISSN 0006-2960. PMID 9585570. doi:10.1021/bi980026r.

[16] Venkatesh K, Prasanth B, Rajesh P, Annie JG, Mukesh P, Jesu A. . Biologia. 2014, 39 (3): 395–406. doi:10.2478/s11756-013-0326-8 .

[pmid16913838-17] Sevenich L, Pennacchio LA, Peters C, Reinheckel T. . Biological Chemistry. July 2006, 387 (7): 885–91 [2022-10-31]. PMID 16913838. S2CID 27739485. doi:10.1515/BC.2006.112. （原始内容存档于2022-10-31）.