胱抑素A

血清胱抑素A
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1CYU、1CYV、1DVC、1DVD、1GD3、1GD4、1N9J、1NB3、1NB5、3K9M、3KFQ、3KSE
識別號
别名	CSTA；, AREI, STF1, STFA, Cystatin A, PSS4
外部ID	OMIM：184600 MGI：3645124 HomoloGene：3819 GeneCards：CSTA
相關疾病
	Exfoliative ichthyosis[1]
基因位置（人类）
染色体	3號染色體[2]
终止	122,341,969 bp[2]
基因位置（小鼠）
染色体	小鼠16号染色体[3]
终止	36,008,481 bp[3]
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• peptidase inhibitor activity; • 蛋白酶結合; • protein-macromolecule adaptor activity; • endopeptidase inhibitor activity; • structural molecule activity; • cysteine-type endopeptidase inhibitor activity;
細胞組分	• 細胞質; • 胞內; • cornified envelope; • 細胞外空間; • 细胞核; • 细胞质基质;
生物學過程	• negative regulation of proteolysis; • peptide cross-linking; • negative regulation of peptidase activity; • 細胞粘附; • keratinocyte differentiation; • negative regulation of endopeptidase activity; • cornification; • cell-cell adhesion;
	Sources:Amigo / QuickGO
直系同源
	1475
	433016
	ENSG00000121552
	ENSMUSG00000079597
	P01040
	B2RV77
	NM_005213
	NM_001082547
	NP_005204
	NP_001076016
	維基數據

胱抑素A是一种在人体中由CSTA基因编码的蛋白质。[6][7]

胱抑素超家族包括含有多个胱抑素样序列的蛋白质。一些成员是活性半胱氨酸蛋白酶抑制剂，而其他成员已经失去或可能从未获得这种抑制活性。超家族中有3个抑制家族，包括1型胱抑素（stefin）、2型胱抑素和激肽原。该基因编码一种stefin，起半胱氨酸蛋白酶抑制剂的作用，与木瓜蛋白酶和组织蛋白酶B、H和L形成紧密复合物。该蛋白是角质形成细胞中角化细胞包膜的前体蛋白之一，在表皮发育和维护。Stefin已被提议作为癌症的预后和诊断工具。[7]

相互作用

胱抑素A已被证明与胱抑素B[8][9]和组织蛋白酶L1[9][10]产生相互作用。

参见

肽转运蛋白碳饥饿家族

参考文献

.
GRCh38: Ensembl release 89: ENSG00000121552 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000079597 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
Hsieh WT, Barrick JL, Berrettini WH, Chan MM, Fong D. . Nucleic Acids Res. Jun 1991, 19 (7): 1722. PMC 333958 . PMID 1674139. doi:10.1093/nar/19.7.1722-a.
.
Pavlova, Alona; Björk Ingemar. . Biochemistry (United States). Sep 2003, 42 (38): 11326–33. ISSN 0006-2960. PMID 14503883. doi:10.1021/bi030119v.
Estrada, S; Nycander M; Hill N J; Craven C J; Waltho J P; Björk I. . Biochemistry (UNITED STATES). May 1998, 37 (20): 7551–60. ISSN 0006-2960. PMID 9585570. doi:10.1021/bi980026r.
Majerle, Andreja; Jerala Roman. . Arch. Biochem. Biophys. (United States). Sep 2003, 417 (1): 53–8. ISSN 0003-9861. PMID 12921779. doi:10.1016/S0003-9861(03)00319-9.

阅读

Järvinen M, Rinne A, Hopsu-Havu VK. . Acta Histochem. 1988, 82 (1): 5–18. PMID 3122506. doi:10.1016/s0065-1281(87)80043-0.
Brown WM, Dziegielewska KM. . Protein Sci. 1997, 6 (1): 5–12. PMC 2143511 . PMID 9007972. doi:10.1002/pro.5560060102.
Kos J, Lah TT. . Oncol. Rep. 1998, 5 (6): 1349–61. PMID 9769367. doi:10.3892/or.5.6.1349.
Rinne A, Järvinen M, Räsänen O. . Acta Histochem. 1979, 63 (2): 183–92. PMID 107702. doi:10.1016/s0065-1281(78)80024-5.
Räsänen O, Järvinen M, Rinne A. . Acta Histochem. 1979, 63 (2): 193–6. PMID 107703. doi:10.1016/s0065-1281(78)80025-7.
Rasmussen HH, van Damme J, Puype M, et al. . Electrophoresis. 1993, 13 (12): 960–9. PMID 1286667. S2CID 41855774. doi:10.1002/elps.11501301199.
Madsen P, Rasmussen HH, Leffers H, et al. . J. Invest. Dermatol. 1991, 97 (4): 701–12. PMID 1940442. doi:10.1111/1523-1747.ep12484041.
Hsieh WT, Fong D, Sloane BF, et al. . Genomics. 1991, 9 (1): 207–9. PMID 2004763. doi:10.1016/0888-7543(91)90241-6.
Rinne A, Järvinen M, Dorn A, et al. . Anatomischer Anzeiger. 1986, 161 (3): 215–30. PMID 2424340.
Kartasova T, Cornelissen BJ, Belt P, van de Putte P. . Nucleic Acids Res. 1987, 15 (15): 5945–62. PMC 306060 . PMID 2442723. doi:10.1093/nar/15.15.5945.
Takeda A, Kaji H, Nakaya K, et al. . J. Biochem. 1989, 105 (6): 986–91. PMID 2768224. doi:10.1093/oxfordjournals.jbchem.a122792.
Strauss M, Stollwerk J, Lenarcic B, et al. . Biol. Chem. Hoppe-Seyler. 1989, 369 (9): 1019–30. PMID 3067731. doi:10.1515/bchm3.1988.369.2.1019.
Davies ME, Barrett AJ. . Histochemistry. 1984, 80 (4): 373–7. PMID 6429090. S2CID 13559202. doi:10.1007/BF00495420.
Machleidt W, Borchart U, Fritz H, et al. . Hoppe-Seyler's Z. Physiol. Chem. 1984, 364 (11): 1481–6. PMID 6689312. doi:10.1515/bchm2.1983.364.2.1481.
Söderström KO, Laato M, Wu P, et al. . Int. J. Cancer. 1995, 62 (1): 1–4. PMID 7541394. S2CID 25265556. doi:10.1002/ijc.2910620102.
Tate S, Ushioda T, Utsunomiya-Tate N, et al. . Biochemistry. 1995, 34 (45): 14637–48. PMID 7578072. doi:10.1021/bi00045a004.
Martin JR, Craven CJ, Jerala R, et al. . J. Mol. Biol. 1995, 246 (2): 331–43. PMID 7869384. doi:10.1006/jmbi.1994.0088.
Steinert PM, Marekov LN. . J. Biol. Chem. 1997, 272 (3): 2021–30. PMID 8999895. doi:10.1074/jbc.272.3.2021 .

外部链接

Cystatin: a protein that flips out!相当有趣的PDB结构文章在PDBe （页面存档备份，存于）
肽酶及其抑制剂的MEROPS在线数据库：I25.001

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[1] .

[refGRCh38Ensembl-2] GRCh38: Ensembl release 89: ENSG00000121552 - Ensembl, May 2017

[refGRCm38Ensembl-3] GRCm38: Ensembl release 89: ENSMUSG00000079597 - Ensembl, May 2017

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1674139-6] Hsieh WT, Barrick JL, Berrettini WH, Chan MM, Fong D. . Nucleic Acids Res. Jun 1991, 19 (7): 1722. PMC 333958 . PMID 1674139. doi:10.1093/nar/19.7.1722-a.

[entrez-7] .

[pmid14503883-8] Pavlova, Alona; Björk Ingemar. . Biochemistry (United States). Sep 2003, 42 (38): 11326–33. ISSN 0006-2960. PMID 14503883. doi:10.1021/bi030119v.

[pmid9585570-9] Estrada, S; Nycander M; Hill N J; Craven C J; Waltho J P; Björk I. . Biochemistry (UNITED STATES). May 1998, 37 (20): 7551–60. ISSN 0006-2960. PMID 9585570. doi:10.1021/bi980026r.

[pmid12921779-10] Majerle, Andreja; Jerala Roman. . Arch. Biochem. Biophys. (United States). Sep 2003, 417 (1): 53–8. ISSN 0003-9861. PMID 12921779. doi:10.1016/S0003-9861(03)00319-9.