丙咪嗪
丙咪嗪是一种口服三环类抗抑郁药,主要用于治疗抑鬱。它还可以治疗焦慮和恐慌症。[4][5][6]
臨床資料 | |
---|---|
商品名 | Tofranil, Tofranil-PM, others |
其他名稱 | Melipramine; G-22355 |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682389 |
核准狀況 | |
懷孕分級 | |
给药途径 | By mouth, intramuscular injection |
ATC碼 | |
法律規範狀態 | |
法律規範 |
|
藥物動力學數據 | |
生物利用度 | 94–96%[2] |
血漿蛋白結合率 | 86%[3] |
药物代谢 | Liver (CYP1A2, CYP2C19, CYP2D6)[3] |
代謝產物 | Desipramine[3] |
生物半衰期 | 20 hours[3] |
排泄途徑 | Kidney (80%), fecal (20%)[3] |
识别 | |
| |
CAS号 | 50-49-7 |
PubChem CID | |
IUPHAR/BPS | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
ChEBI | |
ChEMBL | |
PDB配體ID | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.000.039 |
化学 | |
化学式 | C19H24N2 |
摩尔质量 | 280.42 g·mol−1 |
3D模型(JSmol) | |
| |
|
丙咪嗪的常见副作用有口乾、昏睡、頭暈、低血壓、心跳过速、尿瀦留。丙咪嗪过量可能會导致死亡。
丙咪嗪于1951年被发现,并于1957年投入臨床使用。
参考文献
- . Drugs.com. 28 August 2019 [7 February 2020].
- Heck HA, Buttrill SE, Flynn NW, Dyer RL, Anbar M, Cairns T, et al. . Journal of Pharmacokinetics and Biopharmaceutics. June 1979, 7 (3): 233–248. PMID 480146. S2CID 23232584. doi:10.1007/BF01060015.
- . TGA eBusiness Services. PMIP Pty Ltd. 4 June 2013 [16 October 2013]. (原始内容存档于10 December 2019).
- Robert R, Blakeney PE, Villarreal C, Rosenberg L, Meyer WJ. . Journal of the American Academy of Child and Adolescent Psychiatry. July 1999, 38 (7): 873–882. PMID 10405506. doi:10.1097/00004583-199907000-00018.
- Tcheung WJ, Robert R, Rosenberg L, Rosenberg M, Villarreal C, Thomas C, et al. . Pediatric Critical Care Medicine. November 2005, 6 (6): 676–681. PMID 16276335. S2CID 43261789. doi:10.1097/01.pcc.0000165562.04157.da.
- Robert R, Tcheung WJ, Rosenberg L, Rosenberg M, Mitchell C, Villarreal C, et al. . Burns. November 2008, 34 (7): 919–928. PMID 18675519. doi:10.1016/j.burns.2008.04.009.
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