丙咪嗪

丙咪嗪是一种口服三环类抗抑郁药,主要用于治疗抑鬱。它还可以治疗焦慮恐慌症[4][5][6]

丙咪嗪
臨床資料
商品名Tofranil, Tofranil-PM, others
其他名稱Melipramine; G-22355
AHFS/Drugs.comMonograph
MedlinePlusa682389
核准狀況
懷孕分級
给药途径By mouth, intramuscular injection
ATC碼
法律規範狀態
法律規範
  • 限医生处方(S4)
  • 处方药(-only)
  • 处方药(-only) (POM)
  • 处方药(-only)
藥物動力學數據
生物利用度94–96%[2]
血漿蛋白結合率86%[3]
药物代谢Liver (CYP1A2, CYP2C19, CYP2D6)[3]
代謝產物Desipramine[3]
生物半衰期20 hours[3]
排泄途徑Kidney (80%), fecal (20%)[3]
识别
  • 3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine
CAS号50-49-7  checkY
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
PDB配體ID
CompTox Dashboard (EPA)
ECHA InfoCard100.000.039
化学
化学式C19H24N2
摩尔质量280.42 g·mol−1
3D模型(JSmol
  • CN(C)CCCN1c2ccccc2CCc2ccccc21
  • InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3 checkY
  • Key:BCGWQEUPMDMJNV-UHFFFAOYSA-N checkY

丙咪嗪的常见副作用口乾昏睡頭暈低血壓心跳过速尿瀦留。丙咪嗪过量可能會导致死亡。

丙咪嗪于1951年被发现,并于1957年投入臨床使用。

参考文献

  1. . Drugs.com. 28 August 2019 [7 February 2020].
  2. Heck HA, Buttrill SE, Flynn NW, Dyer RL, Anbar M, Cairns T, et al. . Journal of Pharmacokinetics and Biopharmaceutics. June 1979, 7 (3): 233–248. PMID 480146. S2CID 23232584. doi:10.1007/BF01060015.
  3. . TGA eBusiness Services. PMIP Pty Ltd. 4 June 2013 [16 October 2013]. (原始内容存档于10 December 2019).
  4. Robert R, Blakeney PE, Villarreal C, Rosenberg L, Meyer WJ. . Journal of the American Academy of Child and Adolescent Psychiatry. July 1999, 38 (7): 873–882. PMID 10405506. doi:10.1097/00004583-199907000-00018.
  5. Tcheung WJ, Robert R, Rosenberg L, Rosenberg M, Villarreal C, Thomas C, et al. . Pediatric Critical Care Medicine. November 2005, 6 (6): 676–681. PMID 16276335. S2CID 43261789. doi:10.1097/01.pcc.0000165562.04157.da.
  6. Robert R, Tcheung WJ, Rosenberg L, Rosenberg M, Mitchell C, Villarreal C, et al. . Burns. November 2008, 34 (7): 919–928. PMID 18675519. doi:10.1016/j.burns.2008.04.009.
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