TAS2R31
味觉感受器，类型2，成员31，TAS2R31 是一个人类基因组中TAS2R31基因编码的蛋白质，是苦味味觉感受器的一员。[1]这个苦味感受器已被证明在体外可与糖精起反应。[2]
| 味觉感受器，类型2，成员31 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 标识 | |||||||||||||
| 代号 | TAS2R31; T2R31; T2R44; T2R53; TAS2R44 | ||||||||||||
| 扩展标识 | 遗传学：612669 鼠基因：2681304 同源基因：89249 IUPHAR: GeneCards: TAS2R31 Gene | ||||||||||||
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| 直系同源体 | |||||||||||||
| 物种 | 人类 | 小鼠 | |||||||||||
| Entrez | 259290 | 353165 | |||||||||||
| Ensembl | ENSG00000256436 | ENSMUSG00000053217 | |||||||||||
| UniProt | P59538 | Q7TQA8 | |||||||||||
| mRNA序列 | NM_176885 | NM_181276.1 | |||||||||||
| 蛋白序列 | NP_795366 | NP_851793.1 | |||||||||||
| 基因位置 |
Chr 12: 11.18 – 11.18 Mb |
Chr 6: 132.73 – 132.73 Mb | |||||||||||
| PubMed查询 | |||||||||||||
TAS2R31和其它几种苦味感受器也在人类呼吸道平滑肌细胞上表达。它们在这些细胞中的活化会导致细胞内钙离子增加，从而触发钾离子通道打开，使细胞膜超极化，平滑肌放松。因此，这些受体的活化会导致支气管扩张。[3]
该基因的多态性也与甜味剂安赛蜜的苦味感有关。(PMID 23599216)
另见
参考文献
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- Deshpande DA, Wang WC, McIlmoyle EL, Robinett KS, Schillinger RM, An SS, Sham JS, Liggett SB. . Nat. Med. November 2010, 16 (11): 1299–304. PMC 3066567
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延伸阅读
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