S100蛋白

S100蛋白英語:)是一种脊椎动物的低分子量蛋白质家族,具有两个碱性螺旋-环-螺旋结合位点(EF手型)。已知有21种不同的S100蛋白[1]。编码这些蛋白的基因家族的基因以S100为前缀,如S100A1, S100A2, S100A3等。 这一家族的蛋白也被视为是损伤相关分子模式(Damage-associated molecular pattern,DAMP)的分子。

S100/ICaBP type calcium binding domain
Structure of the S100B protein. Based on PyMOL rendering of PDB 1b4c.
鑑定
標誌S_100
PfamPF01023旧版
InterProIPR013787
PROSITEPDOC00275
SCOP1cnp / SUPFAM

相关的人类基因

  • S100A1S100A2S100A3S100A4S100A5S100A6S100A7(银屑病素), S100A8S100A9(8和9的异二聚体称为钙卫蛋白),S100A10S100A11S100A12(钙粒蛋白C),S100A13S100A14S100A15(koebnerisin),S100A16
  • S100B
  • S100P[2][3]


参考文献

  1. Marenholz I, Heizmann CW, Fritz G. . Biochem. Biophys. Res. Commun. October 2004, 322 (4): 1111–22. PMID 15336958. doi:10.1016/j.bbrc.2004.07.096.
  2. Penumutchu, Srinivasa R.; Chou, Ruey-Hwang; Yu, Chin. . PLOS ONE. 2014-08-01, 9 (8): e103947 [2020-09-26]. ISSN 1932-6203. PMC 4118983可免费查阅. PMID 25084534. doi:10.1371/journal.pone.0103947. (原始内容存档于2017-01-12).
  3. Penumutchu, Srinivasa R.; Chou, Ruey-Hwang; Yu, Chin. . Biochemical and Biophysical Research Communications. 2014-10-17, 454 (3): 404–409. ISSN 1090-2104. PMID 25450399. doi:10.1016/j.bbrc.2014.10.048.

延伸阅读

  • Ronald Wolf, O. M. Zack Howard, Hui-Fang Dong, Christopher Voscopoulos, Karen Boeshans, Jason Winston, Rao Divi, Michele Gunsior, Paul Goldsmith, Bijan Ahvazi, Triantafyllos Chavakis, Joost J. Oppenheim and Stuart H. Yuspa. . The Journal of Immunology. 2010, 181 (2): 1499–1506.
  • Ronald Wolf, Francesca Mascia, Alif Dharamsi, O. M. Zack Howard, Christophe Cataisson, Val Bliskovski, Jason Winston, Lionel Feigenbaum, Ulrike Lichti, Thomas Ruzicka Triantafyllos Chavakis, and Stuart H. Yuspa. . Science Translational Medicine. 2010, 2 (61): 61ra90. PMID 21148126. doi:10.1126/scitranslmed.3001108.

外部链接

Template:Nerve tissue protein Template:Tumor markers

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