MK-608

MK-608是一种抗病毒药物，属于腺苷类似物（一种核苷类似物）。它最初由默克公司开发，用于治疗丙型肝炎。虽然它在动物研究中取得了较好的结果，[1][2]但最终在临床试验中失败。[3]后来，它被广泛用于体外及动物的抗病毒研究，并显示出对一系列病毒的活性，如骨痛熱症、[4]蜱传脑炎病毒、[5]脊髓灰質炎病毒、[6][7]以及茲卡病毒。[8][9]

MK-608
臨床資料
其他名稱7-Deaza-2’-C-methyladenosine; 7DMA
法律規範狀態
法律規範
  • 美：Investigational New Drug
识别
  • (2R,3R,4R,5R)-2-(4-Aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol
CAS号443642-29-3  checkY
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
化学
化学式C12H16N4O4
摩尔质量280.28 g·mol−1
3D模型（JSmol）
  • C[C@]1([C@@H]([C@H](O[C@H]1n2ccc3c2ncnc3N)CO)O)O
  • InChI=1S/C12H16N4O4/c1-12(19)8(18)7(4-17)20-11(12)16-3-2-6-9(13)14-5-15-10(6)16/h2-3,5,7-8,11,17-19H,4H2,1H3,(H2,13,14,15)/t7-,8-,11-,12-/m1/s1
  • Key:IRZRJANZDIOOIF-GAJNKVMBSA-N

参考文献
  1. Carroll SS, Ludmerer S, Handt L, Koeplinger K, Zhang NR, Graham D, et al. . Antimicrobial Agents and Chemotherapy. March 2009, 53 (3): 926–34. PMC 2650549 可免费查阅. PMID 19075052. doi:10.1128/AAC.01032-08.
  2. Olsen DB, Davies ME, Handt L, Koeplinger K, Zhang NR, Ludmerer SW, et al. . Antimicrobial Agents and Chemotherapy. February 2011, 55 (2): 937–9. PMC 3028818 可免费查阅. PMID 21115793. doi:10.1128/AAC.00990-10.
  3. Arnold JJ, Sharma SD, Feng JY, Ray AS, Smidansky ED, Kireeva ML, et al. . PLOS Pathogens. 2012, 8 (11): e1003030. PMC 3499576 可免费查阅. PMID 23166498. doi:10.1371/journal.ppat.1003030.
  4. Schul W, Liu W, Xu HY, Flamand M, Vasudevan SG. . The Journal of Infectious Diseases. March 2007, 195 (5): 665–74. PMID 17262707. doi:10.1086/511310 可免费查阅.
  5. Eyer L, Valdés JJ, Gil VA, Nencka R, Hřebabecký H, Šála M, et al. . Antimicrobial Agents and Chemotherapy. September 2015, 59 (9): 5483–93. PMC 4538560 可免费查阅. PMID 26124166. doi:10.1128/AAC.00807-15.
  6. Goris N, De Palma A, Toussaint JF, Musch I, Neyts J, De Clercq K. . Antiviral Research. March 2007, 73 (3): 161–8. PMID 17055073. doi:10.1016/j.antiviral.2006.09.007.
  7. Wu R, Smidansky ED, Oh HS, Takhampunya R, Padmanabhan R, Cameron CE, Peterson BR. . Journal of Medicinal Chemistry. November 2010, 53 (22): 7958–66. PMC 2990348 可免费查阅. PMID 20964406. doi:10.1021/jm100593s.
  8. Eyer L, Nencka R, Huvarová I, Palus M, Joao Alves M, Gould EA, et al. . The Journal of Infectious Diseases. September 2016, 214 (5): 707–11. PMID 27234417. doi:10.1093/infdis/jiw226 可免费查阅.
  9. Zmurko J, Marques RE, Schols D, Verbeken E, Kaptein SJ, Neyts J. . PLOS Neglected Tropical Diseases. May 2016, 10 (5): e0004695. PMC 4862633 可免费查阅. PMID 27163257. doi:10.1371/journal.pntd.0004695.
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