KIRREL3

KIRREL(、類IRRE蛋白3系屬、不規則類視交叉蛋白3系屬(kin of irregular chiasm-like protein 3)、類腎蛋白2(NEPH2))是一種由KIRREL3基因所編碼的人類蛋白質[1]

類IRRE3系屬(果蠅)
(Kin of IRRE like 3)
有效结构
PDB 直系同源检索:PDBe, RCSB
标识
代号 KIRREL3; KIRRE; MRD4; NEPH2; PRO4502
扩展标识 遗传学607761 鼠基因1914953 同源基因57050 GeneCards: KIRREL3 Gene
直系同源体
物种 人类 小鼠
Entrez 84623 67703
Ensembl ENSG00000149571 ENSMUSG00000032036
UniProt Q8IZU9 Q8BR86
mRNA序列 NM_001161707 NM_001190911
蛋白序列 NP_001155179 NP_001177840
基因位置 Chr 11:
126.29 – 126.87 Mb
Chr 9:
34.49 – 35.04 Mb
PubMed查询

NEPH2是類跨膜蛋白腎病蛋白之蛋白質家族的成員,它包括NEPH1(KIRREL)及NEPH3(KIRREL2)。所述之類腎病蛋白之蛋白質可與腎病蛋白CASK進行蛋白質交互作用

功能

NEPH2牽涉突觸的形成。[2] KIRREL3基因功能的破壞和功能異常有關。[3]

NEPH1及NEPH2都參與了腎臟血液過濾(Ultrafiltration (renal))的功能,且位於濾過裂隙中。[4]

註釋

  1. .
  2. Peter Gerke, Thomas Benzing, Martin Höhne, Andreas Kispert, Michael Frotscher, Gerd Walz, Oliver Kretz. . The Journal of Comparative Neurology. 2006-10-01, 498 (4): 466–475 [2019-02-12]. ISSN 0021-9967. PMID 16874800. doi:10.1002/cne.21064. (原始内容存档于2020-03-02).
  3. Kavita Bhalla, Yue Luo, Tim Buchan, Michael A. Beachem, Gregory F. Guzauskas, Sydney Ladd, Shelly J. Bratcher, Richard J. Schroer, Janne Balsamo, Barbara R. DuPont, Jack Lilien, Anand K. Srivastava. . American Journal of Human Genetics. 2008-12, 83 (6): 703–713 [2019-02-12]. ISSN 1537-6605. PMC 2668064可免费查阅. PMID 19012874. doi:10.1016/j.ajhg.2008.10.020. (原始内容存档于2015-07-04).
  4. Elke Neumann-Haefelin, Albrecht Kramer-Zucker, Krasimir Slanchev, Björn Hartleben, Foteini Noutsou, Katrin Martin, Nicola Wanner, Alexander Ritter, Markus Gödel, Philip Pagel, Xiao Fu, Alexandra Müller, Ralf Baumeister, Gerd Walz, Tobias B. Huber. . Human Molecular Genetics. 2010-06-15, 19 (12): 2347–2359 [2019-02-12]. ISSN 1460-2083. PMID 20233749. doi:10.1093/hmg/ddq108. (原始内容存档于2019-07-28).

延伸閱讀

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