CD14

CD14
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	4GLP
識別號
别名	CD14；, entrez:929, CD14 molecule
外部ID	OMIM：158120 MGI：88318 HomoloGene：493 GeneCards：CD14
基因位置（人类）
染色体	5號染色體[1]
终止	140,633,700 bp[1]
基因位置（小鼠）
染色体	小鼠18号染色体[2]
终止	36,859,851 bp[2]
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• lipopolysaccharide binding; • opsonin receptor activity; • lipoteichoic acid binding; • 血浆蛋白结合; • peptidoglycan immune receptor activity; • lipopeptide binding;
細胞組分	• 高尔基体; • 膜; • 细胞膜; • 細胞外區域; • cell surface; • lipopolysaccharide receptor complex; • anchored component of external side of plasma membrane; • 脂筏模型; • anchored component of membrane; • endosome membrane; • 外排體; • external side of plasma membrane; • 細胞外空間; • secretory granule membrane;
生物學過程	• toll-like receptor TLR1:TLR2 signaling pathway; • response to bacterium; • toll-like receptor 4 signaling pathway; • immune system process; • cellular response to diacyl bacterial lipopeptide; • positive regulation of interferon-gamma production; • response to magnesium ion; • response to heat; • response to electrical stimulus; • MyD88-dependent toll-like receptor signaling pathway; • 受体介导的内吞作用; • cellular response to triacyl bacterial lipopeptide; • TRIF-dependent toll-like receptor signaling pathway; • response to tumor necrosis factor; • positive regulation of endocytosis; • cell surface receptor signaling pathway; • response to lipopolysaccharide; • cellular response to lipoteichoic acid; • 吞噬作用; • positive regulation of tumor necrosis factor production; • inflammatory response; • response to ethanol; • I-kappaB kinase/NF-kappaB signaling; • toll-like receptor TLR6:TLR2 signaling pathway; • cellular response to lipopolysaccharide; • response to molecule of bacterial origin; • positive regulation of type I interferon production; • lipopolysaccharide-mediated signaling pathway; • MyD88-independent toll-like receptor signaling pathway; • 细胞凋亡; • 先天免疫系統; • 程序性坏死; • negative regulation of MyD88-independent toll-like receptor signaling pathway; • apoptotic signaling pathway; • toll-like receptor signaling pathway; • neutrophil degranulation; • positive regulation of NIK/NF-kappaB signaling;
	Sources:Amigo / QuickGO
直系同源
	929
	12475
	ENSG00000170458
	ENSMUSG00000051439
	P08571
	P10810
	NM_001174105; NM_000591; NM_001040021; NM_001174104
	NM_009841
	NP_000582; NP_001035110; NP_001167575; NP_001167576
	NP_033971
	維基數據

CD14（cluster of differentiation 14，分化簇14）是一种细胞表面蛋白质，主要在先天免疫系統的巨噬细胞上表达[5]，是最早发现的模式识别受体[6]，能参与识别脂多糖（LPS，一种病原相关分子模式）。

CD14与TLR4等形成识别LPS的复合物

参考文献

GRCh38: Ensembl release 89: ENSG00000170458 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000051439 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
Setoguchi M, Nasu N, Yoshida S, Higuchi Y, Akizuki S, Yamamoto S. . Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. July 1989, 1008 (2): 213–222. PMID 2472171. doi:10.1016/0167-4781(80)90012-3.
Simmons DL, Tan S, Tenen DG, Nicholson-Weller A, Seed B. . Blood. January 1989, 73 (1): 284–289. PMID 2462937. doi:10.1182/blood.V73.1.284.284 .

外部链接

Human CD14 genome location and CD14 gene details page in the UCSC Genome Browser.
PDB中UniProt可用的所有結構信息之概述：P08571 (Monocyte differentiation antigen CD14) 在PDBe-KB。
醫學主題詞表（MeSH）：CD14+Antigens

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170458 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000051439 - Ensembl, May 2017

[3] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2472171-5] Setoguchi M, Nasu N, Yoshida S, Higuchi Y, Akizuki S, Yamamoto S. . Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. July 1989, 1008 (2): 213–222. PMID 2472171. doi:10.1016/0167-4781(80)90012-3.

[pmid2462937-6] Simmons DL, Tan S, Tenen DG, Nicholson-Weller A, Seed B. . Blood. January 1989, 73 (1): 284–289. PMID 2462937. doi:10.1182/blood.V73.1.284.284 .