TLR4

TLR4
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	4G8A、2Z62、2Z63、2Z65、2Z66、3FXI、3UL7、3UL8、3UL9、3ULA
识别号
别名	TLR4；, ARMD10, CD284, TLR-4, TOLL, toll like receptor 4
外部ID	OMIM：603030 MGI：96824 HomoloGene：41317 GeneCards：TLR4
为以下药物的标靶
	resatorvid[1]
基因位置（人类）
染色体	9号染色体[2]
终止	117,724,735 bp[2]
基因位置（小鼠）
染色体	小鼠4号染色体[3]
终止	66,848,521 bp[3]
RNA表达模式
	查阅更多表达数据
基因本体
分子功能	• lipopolysaccharide immune receptor activity; • lipopolysaccharide binding; • 血浆蛋白结合; • transmembrane signaling receptor activity;
细胞组分	• 细胞质; • 膜; • 细胞质的核周区域; • cell surface; • integral component of membrane; • 细胞膜; • endosome membrane; • intrinsic component of plasma membrane; • integral component of plasma membrane; • lipopolysaccharide receptor complex; • external side of plasma membrane;
生物学过程	• positive regulation of MHC class II biosynthetic process; • positive regulation of JNK cascade; • TRIF-dependent toll-like receptor signaling pathway; • cellular response to mechanical stimulus; • positive regulation of interleukin-8 production; • positive regulation of ERK1 and ERK2 cascade; • T-helper 1 type immune response; • positive regulation of platelet activation; • positive regulation of interleukin-1 production; • positive regulation of stress-activated MAPK cascade; • positive regulation of NLRP3 inflammasome complex assembly; • positive regulation of interleukin-12 production; • positive regulation of interferon-alpha production; • I-kappaB phosphorylation; • positive regulation of nitric-oxide synthase biosynthetic process; • positive regulation of B cell proliferation; • defense response to bacterium; • positive regulation of interleukin-6 production; • activation of innate immune response; • positive regulation of tumor necrosis factor production; • 肿瘤坏死因子产生的负调控; • 先天免疫系统; • negative regulation of interleukin-17 production; • I-kappaB kinase/NF-kappaB signaling; • positive regulation of interferon-beta production; • positive regulation of inflammatory response; • toll-like receptor 4 signaling pathway; • positive regulation of macrophage cytokine production; • positive regulation of interleukin-10 production; • immune system process; • astrocyte development; • intestinal epithelial structure maintenance; • positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway; • response to lipopolysaccharide; • cellular response to lipoteichoic acid; • positive regulation of NF-kappaB transcription factor activity; • 免疫反应; • negative regulation of interleukin-23 production; • regulation of inflammatory response; • positive regulation of chemokine production; • lipopolysaccharide-mediated signaling pathway; • detection of fungus; • positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway; • negative regulation of interferon-gamma production; • response to bacterium; • negative regulation of osteoclast differentiation; • B cell proliferation involved in immune response; • positive regulation of nitric oxide biosynthetic process; • negative regulation of interleukin-6 production; • positive regulation of interferon-gamma production; • nitric oxide production involved in inflammatory response; • MyD88-dependent toll-like receptor signaling pathway; • regulation of dendritic cell cytokine production; • positive regulation of gene expression; • negative regulation of ERK1 and ERK2 cascade; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • macrophage activation; • detection of lipopolysaccharide; • cellular response to lipopolysaccharide; • positive regulation of lymphocyte proliferation; • positive regulation of transcription by RNA polymerase II; • MyD88-independent toll-like receptor signaling pathway; • 消息传递; • inflammatory response; • defense response to Gram-negative bacterium; • toll-like receptor signaling pathway; • 进程性坏死; • apoptotic signaling pathway; • negative regulation of MyD88-independent toll-like receptor signaling pathway;
	Sources:Amigo / QuickGO
直系同源
	7099
	21898
	ENSG00000136869
	ENSMUSG00000039005
	O00206
	Q9QUK6
	NM_138557; NM_003266; NM_138554; NM_138556
	NM_021297
	NP_003257; NP_612564; NP_612567
	NP_067272
	维基数据

Toll样受体4（英语：）是由人类基因 TLR4 编码的蛋白质，是一种膜蛋白质，也被称为CD284（分化簇284，cluster of differentiation 284），是模式识别受体中Toll样受体（TLR）家族的成员，可结合其配体脂多糖（LPS）激活NF-κB信号通路，在先天免疫系统中起到重要作用[6]。

参考文献

.
GRCh38: Ensembl release 89: ENSG00000136869 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000039005 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
Vaure C, Liu Y. . Frontiers in Immunology. 2014-07-10, 5: 316. PMC 4090903 . PMID 25071777. doi:10.3389/fimmu.2014.00316.

外部链接

医学主题词表（MeSH）：Toll-Like+Receptor+4
PDB中UniProt可用的所有结构信息之概述：O00206 (Toll-like receptor 4) 在PDBe-KB。

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[1] .

[refGRCh38Ensembl-2] GRCh38: Ensembl release 89: ENSG00000136869 - Ensembl, May 2017

[refGRCm38Ensembl-3] GRCm38: Ensembl release 89: ENSMUSG00000039005 - Ensembl, May 2017

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[Vaure_2014-6] Vaure C, Liu Y. . Frontiers in Immunology. 2014-07-10, 5: 316. PMC 4090903 . PMID 25071777. doi:10.3389/fimmu.2014.00316.