A20 (基因)

A20
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	2EQF、2EQG、2VFJ、3DKB、3OJ3、3OJ4、3VUW、3VUX、3VUY、3ZJD、3ZJE、3ZJF、3ZJG、4ZRH、4ZS5
識別號
别名	TNFAIP3；, A20, OTUD7C, TNFA1P2, AISBL, TNF alpha induced protein 3, AIFBL1
外部ID	OMIM：191163 MGI：1196377 HomoloGene：4582 GeneCards：TNFAIP3
相關疾病
	紅斑性狼瘡、銀屑病[1]
基因位置（人类）
染色体	6號染色體[2]
终止	137,883,312 bp[2]
基因位置（小鼠）
染色体	小鼠10号染色体[3]
终止	18,891,405 bp[3]
RNA表达模式
	; ;
	查阅更多表达数据
基因本體
分子功能	• DNA结合; • 半胱氨酸型肽酶活性; • 鋅離子結合; • 金屬離子結合; • 泛素蛋白轉移酶活性; • 蛋白酶結合; • 蛋白質自締合; • 肽酶活性; • 连接酶活性; • 激酶结合; • K63连接的多聚泛素修饰依赖性蛋白结合; • 泛素结合; • 血浆蛋白结合; • 催化活性; • 巯基依赖性泛素特异性蛋白酶活性; • 水解酶活性; • 相同蛋白质结合; • Lys63特异性去泛素酶活性; • 轉移酶活性;
細胞組分	• 細胞質; • 细胞质基质; • 溶酶体; • 外排體; • 细胞核; • 細胞內膜結合細胞器;
生物學過程	• 生发中心形成的调控; • 肝细胞增殖的正调控; • 內皮細胞凋亡過程的負調控; • 白细胞介素-1β产生的负调控; • 平滑肌細胞增殖的負調控; • 血管创伤愈合的调控; • B-1 B細胞穩態; • protein K48-linked deubiquitination; • positive regulation of protein catabolic process; • negative regulation of cyclin-dependent protein serine/threonine kinase activity; • 宿主对病毒防御反应的调控; • 泛素依赖性蛋白质分解代谢过程中的蛋白质去蛋白化; • negative regulation of toll-like receptor 2 signaling pathway; • negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway; • 肿瘤坏死因子介导的信号通路的调控; • negative regulation of interleukin-6 production; • negative regulation of B cell activation; • negative regulation of toll-like receptor 5 signaling pathway; • tolerance induction to lipopolysaccharide; • response to muramyl dipeptide; • negative regulation of chronic inflammatory response; • negative regulation of cell death; • negative regulation of I-kappaB kinase/NF-kappaB signaling; • 蛋白酶解; • establishment of protein localization to vacuole; • protein deubiquitination; • negative regulation of protein ubiquitination; • protein K48-linked ubiquitination; • protein K63-linked deubiquitination; • negative regulation of CD40 signaling pathway; • 死亡域受体对外源性凋亡信号通路的负调控; • protein complex oligomerization; • protein K11-linked deubiquitination; • regulation of inflammatory response; • 含有1信號通路的核苷酸結合寡聚結構域的負調控; • negative regulation of innate immune response; • negative regulation of osteoclast proliferation; • 腫瘤壞死因子產生的負調控; • negative regulation of type I interferon production; • 代謝; • inflammatory response; • response to molecule of bacterial origin; • negative regulation of NF-kappaB transcription factor activity; • negative regulation of interleukin-2 production; • negative regulation of inflammatory response; • negative regulation of toll-like receptor 3 signaling pathway; • 含有信号通路的核苷酸结合寡聚结构域; • cellular response to lipopolysaccharide; • negative regulation of toll-like receptor 4 signaling pathway; • negative regulation of bone resorption; • cellular response to hydrogen peroxide; • 细胞凋亡; • protein ubiquitination; • 细胞骨架组织; • 细胞迁移; • positive regulation of Wnt signaling pathway; • protein K29-linked deubiquitination; • protein K33-linked deubiquitination;
	Sources:Amigo / QuickGO
直系同源
	7128
	21929
	ENSG00000118503
	ENSMUSG00000019850
	P21580
	Q60769
	NM_001270507; NM_001270508; NM_006290
	NM_001166402; NM_009397
	NP_001257436; NP_001257437; NP_006281
	NP_001159874; NP_033423
	維基數據

A20基因（或称为：肿瘤坏死因子α诱导蛋白3，英語：，缩写TNFAIP3）是人类六号染色体上的基因[6][7]，可由肿瘤坏死因子α（TNF-α）诱导表达，是一种去泛素化酶和锌指蛋白，可抑制NF-κB激活和TNF介导的细胞凋亡。A20是一种非常古老的蛋白，在刺胞動物門（水母）中也有带有同源结构域的蛋白[8]。

蛋白质的相互作用

A20蛋白与下列蛋白質进行互作：TNIP1[9]、TRAF1[10][11]、TRAF2[10]、IKBKG[12]、TAX1BP1[13]、YWHAB[14]、YWHAZ[14][15]、TRAF6[11][16]和YWHAH[14][15]。

参考文献

.
GRCh38: Ensembl release 89: ENSG00000118503 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000019850 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
Opipari AW Jr; Boguski MS; Dixit VM. . J Biol Chem. October 1990, 265 (25): 14705–8. PMID 2118515.
. （原始内容存档于2010-12-05）.
Staal J, Driege Y, Haegman M, Borghi A, Hulpiau P, Lievens L, et al. . Frontiers in Immunology. 2018, 9: 1136. PMC 5978004 . PMID 29881386. doi:10.3389/fimmu.2018.01136.
Heyninck, K; De Valck D; Vanden Berghe W; Van Criekinge W; Contreras R; Fiers W; Haegeman G; Beyaert R. . J. Cell Biol. (UNITED STATES). June 1999, 145 (7): 1471–82. ISSN 0021-9525. PMC 2133159 . PMID 10385526. doi:10.1083/jcb.145.7.1471.
Song, H Y; Rothe M; Goeddel D V. . Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES). June 1996, 93 (13): 6721–5. Bibcode:1996PNAS...93.6721S. ISSN 0027-8424. PMC 39093 . PMID 8692885. doi:10.1073/pnas.93.13.6721.
Heyninck, K; Beyaert R. . FEBS Lett. (NETHERLANDS). January 1999, 442 (2–3): 147–50. ISSN 0014-5793. PMID 9928991. S2CID 19072203. doi:10.1016/S0014-5793(98)01645-7.
Zhang, S Q; Kovalenko A; Cantarella G; Wallach D. . Immunity (UNITED STATES). March 2000, 12 (3): 301–11. ISSN 1074-7613. PMID 10755617. doi:10.1016/S1074-7613(00)80183-1.
De Valck, D; Jin D Y; Heyninck K; Van de Craen M; Contreras R; Fiers W; Jeang K T; Beyaert R. . Oncogene (ENGLAND). July 1999, 18 (29): 4182–90. ISSN 0950-9232. PMID 10435631. doi:10.1038/sj.onc.1202787 .
Vincenz, C; Dixit V M. . J. Biol. Chem. (UNITED STATES). August 1996, 271 (33): 20029–34. ISSN 0021-9258. PMID 8702721. doi:10.1074/jbc.271.33.20029 .
De Valck, D; Heyninck K; Van Criekinge W; Vandenabeele P; Fiers W; Beyaert R. . Biochem. Biophys. Res. Commun. (UNITED STATES). September 1997, 238 (2): 590–4. ISSN 0006-291X. PMID 9299557. doi:10.1006/bbrc.1997.7343.
Evans, P C; Taylor E R; Coadwell J; Heyninck K; Beyaert R; Kilshaw P J. . Biochem. J. (England). August 2001, 357 (Pt 3): 617–23. ISSN 0264-6021. PMC 1221992 . PMID 11463333. doi:10.1042/0264-6021:3570617.

外部链接

PDB中UniProt可用的所有結構信息之概述：P21580 (Tumor necrosis factor alpha-induced protein 3) 在PDBe-KB。

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[1] .

[refGRCh38Ensembl-2] GRCh38: Ensembl release 89: ENSG00000118503 - Ensembl, May 2017

[refGRCm38Ensembl-3] GRCm38: Ensembl release 89: ENSMUSG00000019850 - Ensembl, May 2017

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2118515-6] Opipari AW Jr; Boguski MS; Dixit VM. . J Biol Chem. October 1990, 265 (25): 14705–8. PMID 2118515.

[entrez-7] . （原始内容存档于2010-12-05）.

[8] Staal J, Driege Y, Haegman M, Borghi A, Hulpiau P, Lievens L, et al. . Frontiers in Immunology. 2018, 9: 1136. PMC 5978004 . PMID 29881386. doi:10.3389/fimmu.2018.01136.

[pmid10385526-9] Heyninck, K; De Valck D; Vanden Berghe W; Van Criekinge W; Contreras R; Fiers W; Haegeman G; Beyaert R. . J. Cell Biol. (UNITED STATES). June 1999, 145 (7): 1471–82. ISSN 0021-9525. PMC 2133159 . PMID 10385526. doi:10.1083/jcb.145.7.1471.

[pmid8692885-10] Song, H Y; Rothe M; Goeddel D V. . Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES). June 1996, 93 (13): 6721–5. Bibcode:1996PNAS...93.6721S. ISSN 0027-8424. PMC 39093 . PMID 8692885. doi:10.1073/pnas.93.13.6721.

[pmid9928991-11] Heyninck, K; Beyaert R. . FEBS Lett. (NETHERLANDS). January 1999, 442 (2–3): 147–50. ISSN 0014-5793. PMID 9928991. S2CID 19072203. doi:10.1016/S0014-5793(98)01645-7.

[pmid10755617-12] Zhang, S Q; Kovalenko A; Cantarella G; Wallach D. . Immunity (UNITED STATES). March 2000, 12 (3): 301–11. ISSN 1074-7613. PMID 10755617. doi:10.1016/S1074-7613(00)80183-1.

[pmid10435631-13] De Valck, D; Jin D Y; Heyninck K; Van de Craen M; Contreras R; Fiers W; Jeang K T; Beyaert R. . Oncogene (ENGLAND). July 1999, 18 (29): 4182–90. ISSN 0950-9232. PMID 10435631. doi:10.1038/sj.onc.1202787 .

[pmid8702721-14] Vincenz, C; Dixit V M. . J. Biol. Chem. (UNITED STATES). August 1996, 271 (33): 20029–34. ISSN 0021-9258. PMID 8702721. doi:10.1074/jbc.271.33.20029 .

[pmid9299557-15] De Valck, D; Heyninck K; Van Criekinge W; Vandenabeele P; Fiers W; Beyaert R. . Biochem. Biophys. Res. Commun. (UNITED STATES). September 1997, 238 (2): 590–4. ISSN 0006-291X. PMID 9299557. doi:10.1006/bbrc.1997.7343.

[pmid11463333-16] Evans, P C; Taylor E R; Coadwell J; Heyninck K; Beyaert R; Kilshaw P J. . Biochem. J. (England). August 2001, 357 (Pt 3): 617–23. ISSN 0264-6021. PMC 1221992 . PMID 11463333. doi:10.1042/0264-6021:3570617.