齐雷索韦

**齐雷索韦**
臨床資料
商品名	Ziresovir
法律規範狀態
法律規範	美：Investigational New Drug;
识别
	IUPAC命名法 N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxo-3,5-dihydro-2H-1λ6,4-benzothiazepin-4-yl)-6-methylquinazolin-4-amine; ;
CAS号	1422500-60-4
PubChem CID	71262247;
ChemSpider	58810221;
UNII	XCF42D7AG4;
化学
化学式	C22H25N5O3S
摩尔质量	439.5
3D模型（JSmol）	交互式图像;
	SMILES CC1=CC2=C(C=C1)N=C(N=C2NCC3(COC3)N)N4CCS(=O)(=O)C5=CC=CC=C5C4;
	InChI InChI=1S/C22H25N5O3S/c1-15-6-7-18-17(10-15)20(24-12-22(23)13-30-14-22)26-21(25-18)27-8-9-31(28,29)19-5-3-2-4-16(19)11-27/h2-7,10H,8-9,11-14,23H2,1H3,(H,24,25,26); Key:GAAICKUTDBZCMT-UHFFFAOYSA-N;

齐雷索韦（ziresovir、RO-0529、AK0529，化学式C₂₂H₂₅N₅O₃S）是一种抗病毒药，被开发用于治疗呼吸道合胞病毒感染。它作为一种融合抑制剂，在II期临床试验中显示出较好的疗效。[1][2]

参见

Zheng X, Gao L, Wang L, Liang C, Wang B, Liu Y, Feng S, Zhang B, Zhou M, Yu X, Xiang K, Chen L, Guo T, Shen HC, Zou G, Wu JZ, Yun H. Discovery of Ziresovir as a Potent, Selective, and Orally Bioavailable Respiratory Syncytial Virus Fusion Protein Inhibitor. J Med Chem. 2019 Jul 11;62(13):6003-6014. doi:10.1021/acs.jmedchem.9b00654 PMID 31194544
Beigel JH, Nam HH, Adams PL, Krafft A, Ince WL, El-Kamary SS, Sims AC. Advances in respiratory virus therapeutics - A meeting report from the 6th isirv Antiviral Group conference. Antiviral Res. 2019 Jul;167:45-67. PMID 30974127 doi:10.1016/j.antiviral.2019.04.006

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.