返老藥

反老藥(Senolytic)是一類受到基礎科學研究以確定其是否能選擇性地殺死衰老細胞並增進人體健康的小分子物質;[1]這類研究的目標是找出或開發能延緩、阻止、紓解甚至逆轉老化相關疾病的藥物。[2][3]與此類研究相關的一個概念是「凍齡」(senostatic),其意為抑制老化。

研究

目前對返老藥的研究處於初步階段,其中一些已經進入人體試驗階段的早期。[4]目前多數潛在的返老藥,其原本的目的是用作抗癌藥物,像是用於化療的藥物达沙替尼以及實驗性的小分子藥物那維托克(Navitoclax,ABT-263)等是其中的例子。[5][6]

潛在的反老藥

臨床試驗

盡管目前只有少數的返老藥進入臨床測試的階段,但一項人體初步臨床試驗顯示,达沙替尼槲皮素的混合物在患有糖尿病腎臟病變的人類患者中,確會降低部分組織當中衰老細胞的數量。[10]

參見

  • 自噬
  • 老化防護(Geroprotector)
  • 维奈托克(Venetoclax)
  • 抗衰老治療(Senotherapy)

參考資料

  1. Childs, Bennett G; Durik, Matej; Baker, Darren J; van Deursen, Jan M. . Nature Medicine. 8 December 2015, 21 (12): 1424–1435. PMC 4748967可免费查阅. PMID 26646499. doi:10.1038/nm.4000.
  2. Kirkland, James L.; Tchkonia, Tamara. . Experimental Gerontology. August 2015, 68: 19–25. PMC 4412760可免费查阅. PMID 25446976. doi:10.1016/j.exger.2014.10.012.
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  5. Blagosklonny, Mikhail V. . Cancer Biology & Therapy. 28 October 2014, 14 (12): 1092–1097. PMC 3912031可免费查阅. PMID 24345884. doi:10.4161/cbt.27350.
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外部連結

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