脂联素受体1

Adiponectin receptor 1; 脂联素受体1
标识
代号	ADIPOR1; ACDCR1; CGI45; PAQR1; TESBP1A
扩展标识	遗传学：607945 鼠基因：1919924 同源基因：69199 IUPHAR: GeneCards: ADIPOR1 Gene
基因本体论描述
分子功能	· receptor activity; · protein kinase binding; · hormone binding; · identical protein binding; · protein heterodimerization activity;
细胞成分	· plasma membrane; · membrane; · integral component of membrane;
生物过程	· hormone-mediated signaling pathway; · fatty acid oxidation; · negative regulation of cell growth; · leptin-mediated signaling pathway; · adiponectin-activated signaling pathway; · positive regulation of JAK-STAT cascade; · positive regulation of insulin receptor signaling pathway;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体

脂联素受体1（英語：，缩写ADIPOR1）是一种由人类基因 ADIPOR1 编码的蛋白质[1]。

结构

ADIPOR1和G蛋白偶联受体（GPCRs）类似，都拥有7个跨膜结构域。但是ADIPOR1的七跨膜的位置与GPCRs相反，N-端在细胞内，C-端在细胞外，也不能与G蛋白相互作用[1]。

功能

脂联素的受体，ADIPOR1和ADIPOR2，能应答球状或全长的脂联素信号，促使AMPK和PPAR-α配体活性增加，以及脂肪酸的氧化和葡萄糖摄取[1][2]。

参考文献

Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T. . Nature. June 2003, 423 (6941): 762–9. PMID 12802337. doi:10.1038/nature01705.
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延伸阅读

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[pmid12802337-1] Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T. . Nature. June 2003, 423 (6941): 762–9. PMID 12802337. doi:10.1038/nature01705.

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