脂联素

脂联素
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	4DOU
識別號
别名	ADIPOQ；, ACDC, ACRP30, ADIPQTL1, ADPN, APM-1, APM1, GBP28, adiponectin, C1Q and collagen domain containing, Adiponectin
外部ID	OMIM：605441 MGI：106675 HomoloGene：3525 GeneCards：ADIPOQ
基因位置（人类）
染色体	3號染色體[1]
终止	186,858,463 bp[1]
基因位置（小鼠）
染色体	小鼠16号染色体[2]
终止	22,976,778 bp[2]
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• hormone activity; • signaling receptor binding; • 細胞因子活性; • sialic acid binding; • protein homodimerization activity; • 血浆蛋白结合; • 相同蛋白质结合; • extracellular matrix structural constituent;
細胞組分	• cell surface; • 内质网; • 膠原蛋白; • 細胞外空間; • 細胞外區域; • 大分子复合体; • collagen-containing extracellular matrix;
生物學過程	• positive regulation of glucose import; • positive regulation of protein phosphorylation; • negative regulation of receptor binding; • low-density lipoprotein particle clearance; • negative regulation of blood pressure; • negative regulation of macrophage differentiation; • negative regulation of synaptic transmission; • generation of precursor metabolites and energy; • cellular response to epinephrine stimulus; • negative regulation of gluconeogenesis; • regulation of glucose metabolic process; • 昼夜节律; • fatty acid oxidation; • positive regulation of interleukin-8 production; • glucose metabolic process; • protein heterotrimerization; • negative regulation of heterotypic cell-cell adhesion; • response to ethanol; • negative regulation of inflammatory response; • cellular response to cAMP; • positive regulation of protein kinase A signaling; • negative regulation of platelet-derived growth factor receptor signaling pathway; • positive regulation of signal transduction; • positive regulation of protein metabolic process; • negative regulation of fat cell differentiation; • response to linoleic acid; • detection of oxidative stress; • glucose homeostasis; • adiponectin-activated signaling pathway; • response to tumor necrosis factor; • positive regulation of blood pressure; • response to nutrient levels; • positive regulation of cholesterol efflux; • negative regulation of MAP kinase activity; • cellular response to insulin stimulus; • positive regulation of peptidyl-tyrosine phosphorylation; • fatty acid beta-oxidation; • 腫瘤壞死因子產生的負調控; • protein localization to plasma membrane; • negative regulation of hormone secretion; • protein homooligomerization; • response to sucrose; • positive regulation of metanephric glomerular visceral epithelial cell development; • positive regulation of renal albumin absorption; • negative regulation of granulocyte differentiation; • response to nutrient; • negative regulation of protein autophosphorylation; • negative regulation of intracellular protein transport; • membrane depolarization; • response to glucose; • positive regulation of myeloid cell apoptotic process; • negative regulation of I-kappaB kinase/NF-kappaB signaling; • negative regulation of metanephric mesenchymal cell migration; • negative regulation of cell migration; • positive regulation of fatty acid metabolic process; • brown fat cell differentiation; • positive regulation of cAMP-dependent protein kinase activity; • positive regulation of glycogen (starch) synthase activity; • negative regulation of transcription, DNA-templated; • negative regulation of DNA biosynthetic process; • positive regulation of protein kinase activity; • response to hypoxia; • negative regulation of phagocytosis; • membrane hyperpolarization; • negative regulation of tumor necrosis factor-mediated signaling pathway; • positive regulation of monocyte chemotactic protein-1 production; • response to glucocorticoid; • response to activity; • negative regulation of platelet-derived growth factor receptor-alpha signaling pathway; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • negative regulation of ERK1 and ERK2 cascade; • negative regulation of macrophage derived foam cell differentiation; • regulation of fatty acid biosynthetic process; • regulation of signaling receptor activity; • negative regulation of vascular associated smooth muscle cell proliferation; • negative regulation of vascular associated smooth muscle cell migration; • response to bacterium; • positive regulation of cold-induced thermogenesis; • negative regulation of cold-induced thermogenesis; • 訊息傳遞;
	Sources:Amigo / QuickGO
直系同源
	9370
	11450
	ENSG00000181092
	ENSMUSG00000022878
	Q15848
	Q60994
	NM_001177800; NM_004797
	NM_009605
	NP_001171271; NP_004788
	NP_033735
	維基數據

脂连蛋白（英語：，亦称为脂联素）是一种主要由脂肪细胞分泌的蛋白质激素，由ADIPOQ基因所编码[5]，含244个氨基酸。成人体内的脂联素水平与脂肪储量负相关。

结构

脂联素包含244个氨基酸，可分为4个结构域。从其N端起算，第一个是使其定位于细胞外的信号序列，第二个区域较短且在物种间高度变异，第三个65个氨基酸的区域与膠原蛋白相似，最后一个是脂联素的球状结构域。总的上看，这一蛋白与补体片段C1q相似。其中球状结构域的三维结构已经测定，结构上与TNFα非常相似，但在氨基酸序列上却差异巨大[6]。

受体

脂联素可与几种受体结合，两种受体与G蛋白偶联受体有同源性，一种属于钙粘蛋白家族[7][8]：

脂联素受体1 – ADIPOR1
脂联素受体2 – ADIPOR2
T-cadherin - CDH13

These have distinct tissue specificities within the body and have different affinities to the various forms of adiponectin. The receptors affect the downstream target AMP kinase, an important cellular metabolic rate control point. Expression of the receptors is correlated with insulin levels, as well as reduced in mouse models of diabetes, particularly in 骨骼肌 and adipose tissue.[9][10]

参考文献

GRCh38: Ensembl release 89: ENSG00000181092 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000022878 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
Maeda K, Okubo K, Shimomura I, Funahashi T, Matsuzawa Y, Matsubara K. . Biochem. Biophys. Res. Commun. April 1996, 221 (2): 286–9. PMID 8619847. doi:10.1006/bbrc.1996.0587.
Shapiro L, Scherer PE. . Curr. Biol. March 1998, 8 (6): 335–8. PMID 9512423. doi:10.1016/S0960-9822(98)70133-2.
Yamauchi, T; Kamon, J; Ito, Y; Tsuchida, A; Yokomizo, T; Kita, S; et al. . Nature. 2003, 423 (6941): 762–9. PMID 12802337. doi:10.1038/nature01705. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
Hug, C; Wang, J; Ahmad, NS; Bogan, JS; Tsao, TS; Lodish, HF. . Proc. Natl. Acad. Sci. U.S.A. 2004, 101 (28): 10308–13. PMC 478568 . PMID 15210937. doi:10.1073/pnas.0403382101. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
Fang, X; Sweeney, G. . Biochem. Soc. Trans. 2006, 34 (Pt 5): 798–801. PMID 17052201. doi:10.1042/BST0340798. 已忽略未知参数|author-separator= (帮助); 已忽略未知参数|author-name-separator= (帮助)
Bonnard, C; Durand, A; Vidal, H; Rieusset, J. . Diabetes Metab. 2008, 34 (1): 52–61. PMID 18222103. doi:10.1016/j.diabet.2007.09.006. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000181092 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022878 - Ensembl, May 2017

[3] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8619847-5] Maeda K, Okubo K, Shimomura I, Funahashi T, Matsuzawa Y, Matsubara K. . Biochem. Biophys. Res. Commun. April 1996, 221 (2): 286–9. PMID 8619847. doi:10.1006/bbrc.1996.0587.

[pmid9512423-6] Shapiro L, Scherer PE. . Curr. Biol. March 1998, 8 (6): 335–8. PMID 9512423. doi:10.1016/S0960-9822(98)70133-2.

[pmid12802337-7] Yamauchi, T; Kamon, J; Ito, Y; Tsuchida, A; Yokomizo, T; Kita, S; et al. . Nature. 2003, 423 (6941): 762–9. PMID 12802337. doi:10.1038/nature01705. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

[pmid15210937-8] Hug, C; Wang, J; Ahmad, NS; Bogan, JS; Tsao, TS; Lodish, HF. . Proc. Natl. Acad. Sci. U.S.A. 2004, 101 (28): 10308–13. PMC 478568 . PMID 15210937. doi:10.1073/pnas.0403382101. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

[pmid17052201-9] Fang, X; Sweeney, G. . Biochem. Soc. Trans. 2006, 34 (Pt 5): 798–801. PMID 17052201. doi:10.1042/BST0340798. 已忽略未知参数|author-separator= (帮助); 已忽略未知参数|author-name-separator= (帮助)

[pmid18222103-10] Bonnard, C; Durand, A; Vidal, H; Rieusset, J. . Diabetes Metab. 2008, 34 (1): 52–61. PMID 18222103. doi:10.1016/j.diabet.2007.09.006. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)