胰岛素样生长因子1

胰岛素样生长因子1（英語：，IGF-1）也被称为生长调节素C（somatomedin C），是一个由人类基因 IGF1 编码的蛋白质[6][7]。在1970年代，IGF-1也曾经被称为“酸硫化因子”[8]，並認為其作用为“不受抑制的胰岛样活力”（nonsuppressible insulin-like activity，NSILA）。

胰岛素样生长因子1
已知的結構 PDB 直系同源搜索: PDBe RCSB PDBID列表 1B9G、​1GZR、​1GZY、​1GZZ、​1H02、​1H59、​1IMX、​1PMX、​1TGR、​1WQJ、​2DSR、​2GF1、​3GF1、​3LRI、​1BQT、​4XSS
識別號
别名	IGF1；, IGF-I, IGF1A, IGFI, MGF, insulin like growth factor 1, IGF
外部ID	OMIM：147440 MGI：96432 HomoloGene：515 GeneCards：IGF1
相關疾病
growth delay due to insulin-like growth factor type 1 deficiency[1]
基因位置（人类） 染色体 12號染色體[2] 基因座 12q23.2 起始 102,395,874 bp[2] 终止 102,481,744 bp[2]
基因位置（小鼠） 染色体 小鼠10号染色体[3] 基因座 10 C1|10 43.7 cM 起始 87,694,127 bp[3] 终止 87,772,904 bp[3]
RNA表达模式
查阅更多表达数据
基因本體 分子功能 • hormone activity • insulin receptor binding • 生長因子活性 • integrin binding • 血浆蛋白结合 • insulin-like growth factor receptor binding 細胞組分 • 細胞外區域 • exocytic vesicle • insulin-like growth factor binding protein complex • platelet alpha granule lumen • insulin-like growth factor ternary complex • alphav-beta3 integrin-IGF-1-IGF1R complex • 细胞膜 • 細胞外空間 生物學過程 • positive regulation of transcription regulatory region DNA binding • 骨骼系统的发生 • positive regulation of glucose import • muscle organ development • positive regulation of Ras protein signal transduction • response to heat • positive regulation of cardiac muscle hypertrophy • positive regulation of smooth muscle cell migration • 脫氧核糖核酸複製 • positive regulation of insulin-like growth factor receptor signaling pathway • phosphatidylinositol 3-kinase signaling • positive regulation of DNA binding • Ras protein signal transduction • 細胞增殖 • positive regulation of mitotic nuclear division • positive regulation of trophectodermal cell proliferation • positive regulation of glycogen biosynthetic process • positive regulation of fibroblast proliferation • ERK1 and ERK2 cascade • negative regulation of extrinsic apoptotic signaling pathway • cell activation • negative regulation of oocyte development • positive regulation of transcription, DNA-templated • bone mineralization involved in bone maturation • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of MAPK cascade • proteoglycan biosynthetic process • positive regulation of activated T cell proliferation • positive regulation of epithelial cell proliferation • negative regulation of release of cytochrome c from mitochondria • protein stabilization • myotube cell development • positive regulation of DNA replication • myoblast proliferation • skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration • positive regulation of protein secretion • positive regulation of glycoprotein biosynthetic process • 基因調節 • phosphatidylinositol-mediated signaling • positive regulation of smooth muscle cell proliferation • 肌肉肥大 • Akt/PKB信号通路 • regulation of multicellular organism growth • positive regulation of cell migration • platelet degranulation • positive regulation of calcineurin-NFAT signaling cascade • positive regulation of phosphatidylinositol 3-kinase signaling • myoblast differentiation • glycolate metabolic process • positive regulation of glycolytic process • negative regulation of smooth muscle cell apoptotic process • 訊息傳遞 • positive regulation of transcription by RNA polymerase II • positive regulation of cell growth involved in cardiac muscle cell development • positive regulation of cell population proliferation • positive regulation of osteoblast differentiation • activation of protein kinase B activity • insulin-like growth factor receptor signaling pathway • negative regulation of apoptotic process • positive regulation of tyrosine phosphorylation of STAT protein • regulation of signaling receptor activity • positive regulation of gene expression • negative regulation of gene expression • cellular response to amyloid-beta • positive regulation of vascular associated smooth muscle cell proliferation • negative regulation of vascular associated smooth muscle cell apoptotic process • 白细胞介素-1β产生的负调控 • 腫瘤壞死因子產生的負調控 • negative regulation of neuroinflammatory response • negative regulation of amyloid-beta formation Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	3479	16000
Ensembl	ENSG00000017427	ENSMUSG00000020053
UniProt	P05019	P05017
mRNA​序列	NM_000618 ​NM_001111283 ​NM_001111284 ​NM_001111285	NM_001111274 ​NM_001111275 ​NM_001111276 ​NM_010512 ​NM_184052 ​NM_001314010
蛋白序列	NP_000609 ​NP_001104753 ​NP_001104754 ​NP_001104755	NP_001104744 ​NP_001104745 ​NP_001104746 ​NP_001300939 ​NP_034642
基因位置​（UCSC）	Chr 12: 102.4 – 102.48 Mb	Chr 10: 87.69 – 87.77 Mb
PubMed​查找	[4]	[5]
維基數據

IGF-1是一个在三级结构上与胰岛素类似的激素，在儿童成长发育中有重要作用，并持续在成人的合成代谢中起作用。一种人工合成的IGF-1类似物，美卡舍明，用于治疗发育停滞[9]。

IGF-1蛋白由一个肽链构成，包括70个氨基酸残基和三个分子内二硫键，分子量为7,649道尔顿[10]。

已经发现,垂体前部的生长激素（GH）分泌受到GH释放激素( GHRH )和生长抑素的调节，GHRH和生长抑素之间的相互作用引起搏动性GH分泌，在青春期最高。GH诱导肝脏中胰岛素样生长因子1的产生，并调节许多其他组织中IGF-1的旁分泌。IGF-1是GH的合成代谢和促有丝分裂活性的介体。