紅杉醇

紅杉醇Sequoyitol西曲依醇)是肌醇的甲基衍生物,常被用於治療糖尿病[1][2][3]

  • 《本草推陳》(1960)記載,紫杉具有通經、利尿,治腎臟病、糖尿病等功用,梁敬鈺等人(1996)發現紫杉對於降低血糖的有效成分為紅杉醇。
  • 紅杉醇存在於下列植物中;裸子植物(尤其是紅豆杉銀杏)、豆科三葉草屬馬兜鈴科[4][5],雖然裸子植物中的紅杉醇含量較高,但裸子植物生長較慢,用來製藥並不符合經濟效率,因此有許多人試著從其他植物中取得紅杉醇,並已取得相當成果[6][7][8]

注釋

  1. Hypoglycemic and Antiplatelet Constituents of Taxus mairei,郭代璜等人,中華藥學雜誌1994;46(3)。
  2. Hopoglycemic effects of the wood of Taxus yunnanensis on streptozotocin-induced diabetic rats and its active components, Phytomedicine 2006:109-114.
  3. Study on the Hypoglycemic Mechanism of Sequoyitol and Inositol Substances, 2010.
  4. 紅杉醇在植物種類中的分佈,王音音、李桂峰、王亭,今日藥學2008;17(1)。
  5. 紅豆杉(Taxus Chinensis)植物替代資源的調查研究,動物營養與飼料科學2007。
  6. European Patent Application 02774265.9:A Natural Compound Useful for Treating Diabetes, its preparation and use.
  7. United States Patent Application 10/531,049:Natural Compound Useful for Treating Diabetes, its preparation and use.
  8. 中華人民共和國專利200710028333.5:A Method for a Sequoyitol-Containing Extract Obtaining from the Genus of Trifolium, Soybean and Ginkgo Biloba and use thereof.
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