孕三烯酮

孕三烯酮（英語：）是一种用于治疗子宮內膜異位症的药物[2][3]，也用于治疗子宮肌瘤、經血過多以及进行生育控制[1]。孕三烯酮通常单独使用，不与其他药物联合使用[4]，可由口服给药或阴道内给药[1]。

孕三烯酮
臨床資料
商品名Dimetriose, Dimetrose, Nemestran, others
其他名稱Ethylnorgestrienone; A-46745; R2323; R-2323; RU-2323; 17α-Ethynyl-18-methyl-δ9,11-19-nortestosterone; 17α-Ethynyl-18-methylestra-4,9,11-trien-17β-ol-3-one; 13β-Ethyl-18,19-dinor-17α-pregna-4,9,11-trien-20-yn-17β-ol-3-one
AHFS/Drugs.com国际药品名称
懷孕分級
  • X
给药途径By mouth, vaginal[1]
藥物類別Progestin; Progestogen; Antiprogestogen; Androgen; Anabolic steroid; Steroidogenesis inhibitor; Antiestrogen
ATC碼
藥物動力學數據
血漿蛋白結合率To albumin[1]
药物代谢Liver (hydroxylation)[1]
生物半衰期27.3 hours[1]
排泄途徑Urine and bile[1]
识别
  • (8S,13S,14S,17R)-13-ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
CAS号16320-04-0  checkY
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.210.606
化学
化学式C21H24O2
摩尔质量308.41 g/mol
3D模型（JSmol）
  • O=C4\C=C3/C(=C2/C=C\[C@]1([C@@H](CC[C@]1(C#C)O)[C@@H]2CC3)CC)CC4
  • InChI=1S/C21H24O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,9,11,13,18-19,23H,3,5-8,10,12H2,1H3/t18-,19+,20+,21+/m1/s1 checkY
  • Key:BJJXHLWLUDYTGC-ANULTFPQSA-N checkY

参考文献
  1. Eric J. Thomas; John Rock. . Springer Science & Business Media. 6 December 2012: 228, 232, 234. ISBN 978-94-011-3864-2.
  2. Coutinho EM. . Prog. Clin. Biol. Res. 1990, 323: 233–40. PMID 2406749.
  3. Dr. Ian Morton; I.K. Morton; Judith M. Hall. . Springer Science & Business Media. 31 October 1999: 132–. ISBN 978-0-7514-0499-9.

延伸阅读
  • Coutinho E, Gonçalves MT, Azadian-Boulanger G, Silva AR. . Contrib Gynecol Obstet. 1987, 16: 227–35. PMID 3691096. doi:10.1159/000414891 (不活跃 2018-10-13).
  • Coutinho EM. . Prog. Clin. Biol. Res. 1990, 323: 233–40. PMID 2406749.
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