WB-4101

WB-4101，是一种化合物，可以作α1B-肾上腺素能受体的拮抗剂。1969年，WB-4101是首批为该受体开发的选择性拮抗剂之一，常用于肾上腺素受体的研究，作爲开发更具选择性药物的先导化合物。[1][2][3][4][5][6]

WB-4101
识别
  • 2-(2,6-Dimethoxyphenoxyethyl)aminomethyl-1,4-benzodioxane
CAS号613-67-2  checkY
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
CompTox Dashboard (EPA)
化学
化学式C19H23NO5
摩尔质量345.389
3D模型（JSmol）
  • COc1cccc(c1OCCNCC2COc3ccccc3O2)OC
  • InChI=1S/C19H23NO5/c1-21-17-8-5-9-18(22-2)19(17)23-11-10-20-12-14-13-24-15-6-3-4-7-16(15)25-14/h3-9,14,20H,10-13H2,1-2H3
  • Key:GYSZUJHYXCZAKI-UHFFFAOYSA-N

參見
  • 苯二恶烷

参考文獻
  1. . Journal of Medicinal Chemistry. March 1969, 12 (2): 326–9. PMID 5791620. doi:10.1021/jm00302a033.
  2. . Molecular Pharmacology. April 1986, 29 (4): 321–30. PMID 3010073.
  3. . Farmaco. April 1998, 53 (4): 278–86. PMID 9658586. doi:10.1016/S0014-827X(98)00022-6.
  4. . Pharmaceutica Acta Helvetiae. March 2000, 74 (2–3): 181–90. PMID 10812956. doi:10.1016/S0031-6865(99)00049-7.
  5. . European Journal of Medicinal Chemistry. December 2012, 58: 184–91. PMID 23124215. doi:10.1016/j.ejmech.2012.09.049.
  6. . Journal of Medicinal Chemistry. August 2013, 56 (16): 6402–12. PMID 23902232. doi:10.1021/jm400867d.
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