TLR2

TLR2
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1FYW、1FYX、1O77、2Z7X、2Z80
識別號
别名	TLR2；, CD282, TIL4, toll like receptor 2
外部ID	OMIM：603028 MGI：1346060 HomoloGene：20695 GeneCards：TLR2
基因位置（人类）
染色体	4號染色體[1]
终止	153,706,260 bp[1]
基因位置（小鼠）
染色体	小鼠3号染色体[2]
终止	83,749,074 bp[2]
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• pattern recognition receptor activity; • lipopolysaccharide binding; • Toll-like receptor binding; • triacyl lipopeptide binding; • 血浆蛋白结合; • peptidoglycan binding; • protein heterodimerization activity; • lipopolysaccharide immune receptor activity; • transmembrane signaling receptor activity; • lipopeptide binding;
細胞組分	• 細胞質; • integral component of membrane; • phagocytic vesicle membrane; • 高尔基体; • 膜; • intrinsic component of plasma membrane; • 细胞膜; • Toll-like receptor 1-Toll-like receptor 2 protein complex; • integral component of plasma membrane; • 脂筏模型; • cytoplasmic vesicle; • cell projection; • cell surface; • cell body;
生物學過程	• interleukin-10 production; • positive regulation of interferon-beta production; • defense response to Gram-positive bacterium; • positive regulation of interleukin-18 production; • positive regulation of toll-like receptor signaling pathway; • toll-like receptor TLR1:TLR2 signaling pathway; • positive regulation of inflammatory response; • cellular response to bacterial lipopeptide; • positive regulation of interleukin-12 production; • immune system process; • detection of diacyl bacterial lipopeptide; • cellular response to diacyl bacterial lipopeptide; • I-kappaB phosphorylation; • positive regulation of nitric-oxide synthase biosynthetic process; • MyD88-dependent toll-like receptor signaling pathway; • cellular response to triacyl bacterial lipopeptide; • detection of triacyl bacterial lipopeptide; • positive regulation of Wnt signaling pathway; • positive regulation of gene expression; • cellular response to lipoteichoic acid; • positive regulation of NF-kappaB transcription factor activity; • 免疫反应; • positive regulation of interleukin-8 production; • positive regulation of interleukin-6 production; • positive regulation of tumor necrosis factor production; • positive regulation of chemokine production; • 先天免疫系統; • inflammatory response; • toll-like receptor TLR6:TLR2 signaling pathway; • response to molecule of bacterial origin; • 訊息傳遞; • positive regulation of transcription by RNA polymerase II; • 细胞凋亡; • response to lipopolysaccharide; • response to progesterone; • toll-like receptor signaling pathway; • response to insulin; • central nervous system myelin formation; • nitric oxide metabolic process; • response to fatty acid; • leukotriene metabolic process; • toll-like receptor 2 signaling pathway; • positive regulation of oligodendrocyte differentiation; • response to bacterial lipoprotein; • negative regulation of cell population proliferation; • response to toxic substance; • response to hypoxia; • positive regulation of interleukin-10 production; • lipopolysaccharide-mediated signaling pathway; • microglial cell activation;
	Sources:Amigo / QuickGO
直系同源
	7097
	24088
	ENSG00000137462
	ENSMUSG00000027995
	O60603
	Q9QUN7
NM_003264; NM_001318787; NM_001318789; NM_001318790; NM_001318791;
	NM_001318793; NM_001318795; NM_001318796
	NM_011905
NP_001305716; NP_001305718; NP_001305719; NP_001305720; NP_001305722;
	NP_001305724; NP_001305725; NP_003255
	NP_036035
	維基數據

Toll样受体2（英語：）是由人类基因 TLR2 编码的蛋白质[5]，是一种膜蛋白质和受体，也被称为CD282（分化簇282，cluster of differentiation 282），是Toll样受体（TLR）家族的成员，在免疫系统中起到重要作用。

参考文献

GRCh38: Ensembl release 89: ENSG00000137462 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000027995 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
Rock FL, Hardiman G, Timans JC, Kastelein RA, Bazan JF. . Proceedings of the National Academy of Sciences of the United States of America. January 1998, 95 (2): 588–93. Bibcode:1998PNAS...95..588R. PMC 18464 . PMID 9435236. doi:10.1073/pnas.95.2.588.

延伸阅读

Aderem A, Ulevitch RJ. . Nature. August 2000, 406 (6797): 782–7. PMID 10963608. S2CID 4410405. doi:10.1038/35021228.
Ey B, Eyking A, Klepak M, Salzman NH, Göthert JR, Rünzi M, Schmid KW, Gerken G, Podolsky DK, Cario E. . J. Immunol. June 2013, 190 (11): 5676–88. PMC 3659955 . PMID 23636052. doi:10.4049/jimmunol.1201592.
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外部链接

醫學主題詞表（MeSH）：TLR2+protein,+human

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000137462 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027995 - Ensembl, May 2017

[3] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9435236-5] Rock FL, Hardiman G, Timans JC, Kastelein RA, Bazan JF. . Proceedings of the National Academy of Sciences of the United States of America. January 1998, 95 (2): 588–93. Bibcode:1998PNAS...95..588R. PMC 18464 . PMID 9435236. doi:10.1073/pnas.95.2.588.