TAS2R38
TAS2R38是一种苦味味觉感受器[1][2]，该感受器可以尝出苯硫脲[3]和丙硫氧嘧啶[4]或者相关物质的苦味。这一点和大多数苦味感受器有所不同，即该感受器是对某类物质敏感，而大多数感受器则不会表现出强烈的选择性，能对多种物质做出响应[5]。该感受器所能尝出的相应物质大量存在于西兰花、卷心菜以及其它十字花科植物中[5]，例如：葡萄糖异硫氰酸盐及其相关产物异硫氰酸酯。目前全球人类中，约有75%该感受器相关基因正常，即，可以尝出苦味。而剩下的25%则无法尝出这类的苦味，或者敏感度较低[6]。 不过目前的研究表明该感受器相关基因的变异与否，并不是决定某个人是否此类苦味物质的超级品尝家的唯一因素。[7]
| 味觉感受器，类型2，成员38 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 标识 | |||||||||||||
| 代号 | TAS2R38; PTC; T2R61 | ||||||||||||
| 扩展标识 | 遗传学：607751 鼠基因：2681306 同源基因：47976 GeneCards: TAS2R38 Gene | ||||||||||||
| |||||||||||||
| 直系同源体 | |||||||||||||
| 物种 | 人类 | 小鼠 | |||||||||||
| Entrez | 5726 | 387513 | |||||||||||
| Ensembl | ENSG00000183609 | ENSMUSG00000058250 | |||||||||||
| UniProt | P59533 | A0PK79 | |||||||||||
| mRNA序列 | NM_176817 | NM_001001451 | |||||||||||
| 蛋白序列 | NP_789787 | NP_001001451 | |||||||||||
| 基因位置 |
Chr 7: 141.32 – 141.32 Mb |
Chr 6: 40.54 – 40.54 Mb | |||||||||||
| PubMed查询 | |||||||||||||
引用
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深入阅读
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