STAT6

Signal transducer and activator of transcription 6, interleukin-4 induced; 信号转导及转录激活蛋白6，白介素-4诱导
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	1OJ5
标识
代号	STAT6; D12S1644; IL-4-STAT; STAT6B; STAT6C
扩展标识	遗传学：601512 鼠基因：103034 同源基因：2373 ChEMBL: 5401 GeneCards: STAT6 Gene
基因本体论描述
分子功能	· RNA polymerase II core promoter sequence-specific DNA binding; · sequence-specific DNA binding transcription factor activity; · signal transducer activity; · calcium ion binding; · protein binding; · identical protein binding;
细胞成分	· nuclear chromatin; · nucleus; · nucleolus; · cytoplasm; · cytosol;
生物过程	· negative regulation of transcription from RNA polymerase II promoter; · T-helper 1 cell lineage commitment; · negative regulation of type 2 immune response; · transcription, DNA-dependent; · regulation of transcription from RNA polymerase II promoter; · signal transduction; · cytokine-mediated signaling pathway; · mammary gland epithelial cell proliferation; · regulation of cell proliferation; · positive regulation of transcription from RNA polymerase II promoter; · positive regulation of isotype switching to IgE isotypes; · mammary gland morphogenesis;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体

信号转导及转录激活蛋白6（英語：，STAT6）是一种由人类基因STAT6 编码的转录因子[1][2]。

相互作用

STAT3能与下列蛋白質发生交互作用：

EP300,[3] CREB-binding protein,[3][4] NFKB1,[5] Nuclear receptor coactivator 1,[4][6] IRF4[7]和SND1[8]。

另见

白细胞介素-4

参考文献

Leek JP, Hamlin PJ, Bell SM, Lench NJ. . Cytogenet. Cell Genet. 1997, 79 (3–4): 208–9. PMID 9605853. doi:10.1159/000134723.
Hou J, Schindler U, Henzel WJ, Ho TC, Brasseur M, McKnight SL. . Science. September 1994, 265 (5179): 1701–6. PMID 8085155. doi:10.1126/science.8085155.
McDonald, C; Reich N C. . J. Interferon Cytokine Res. (UNITED STATES). July 1999, 19 (7): 711–22. ISSN 1079-9907. PMID 10454341. doi:10.1089/107999099313550.
Litterst, C M; Pfitzner E. . J. Biol. Chem. (United States). Dec 2001, 276 (49): 45713–21. ISSN 0021-9258. PMID 11574547. doi:10.1074/jbc.M108132200.
Shen, C H; Stavnezer J. . Mol. Cell. Biol. (UNITED STATES). June 1998, 18 (6): 3395–404. ISSN 0270-7306. PMC 108921 . PMID 9584180.
Litterst, Claudia M; Pfitzner Edith. . J. Biol. Chem. (United States). September 2002, 277 (39): 36052–60. ISSN 0021-9258. PMID 12138096. doi:10.1074/jbc.M203556200.
Gupta, S; Jiang M; Anthony A; Pernis A B. . J. Exp. Med. (UNITED STATES). Dec 1999, 190 (12): 1837–48. ISSN 0022-1007. PMC 2195723 . PMID 10601358. doi:10.1084/jem.190.12.1837.
Yang, Jie; Aittomäki Saara; Pesu Marko; Carter Kara; Saarinen Jussi; Kalkkinen Nisse; Kieff Elliott; Silvennoinen Olli. . EMBO J. (England). September 2002, 21 (18): 4950–8. ISSN 0261-4189. PMC 126276 . PMID 12234934. doi:10.1093/emboj/cdf463.

延伸阅读

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Hou J, Schindler U, Henzel WJ; et al. . Science. 1994, 265 (5179): 1701–6. PMID 8085155. doi:10.1126/science.8085155.
Takeda K, Tanaka T, Shi W; et al. . Nature. 1996, 380 (6575): 627–30. PMID 8602263. doi:10.1038/380627a0.
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Mikita T, Campbell D, Wu P; et al. . Mol. Cell. Biol. 1996, 16 (10): 5811–20. PMC 231582 . PMID 8816495.
Shen CH, Stavnezer J. . Mol. Cell. Biol. 1998, 18 (6): 3395–404. PMC 108921 . PMID 9584180.
Leek JP, Hamlin PJ, Bell SM, Lench NJ. . Cytogenet. Cell Genet. 1998, 79 (3–4): 208–9. PMID 9605853. doi:10.1159/000134723.
Mikita T, Kurama M, Schindler U. . J. Immunol. 1998, 161 (4): 1822–8. PMID 9712049.
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McDonald C, Reich NC. . J. Interferon Cytokine Res. 1999, 19 (7): 711–22. PMID 10454341. doi:10.1089/107999099313550.
Harris MB, Chang CC, Berton MT; et al. . Mol. Cell. Biol. 2000, 19 (10): 7264–75. PMC 84719 . PMID 10490661.
Gupta S, Jiang M, Pernis AB. . J. Immunol. 1999, 163 (7): 3834–41. PMID 10490982.
Gupta S, Jiang M, Anthony A, Pernis AB. . J. Exp. Med. 2000, 190 (12): 1837–48. PMC 2195723 . PMID 10601358. doi:10.1084/jem.190.12.1837.
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外部链接

醫學主題詞表（MeSH）：STAT6+Transcription+Factor

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[pmid9605853-1] Leek JP, Hamlin PJ, Bell SM, Lench NJ. . Cytogenet. Cell Genet. 1997, 79 (3–4): 208–9. PMID 9605853. doi:10.1159/000134723.

[pmid8085155-2] Hou J, Schindler U, Henzel WJ, Ho TC, Brasseur M, McKnight SL. . Science. September 1994, 265 (5179): 1701–6. PMID 8085155. doi:10.1126/science.8085155.

[pmid10454341-3] McDonald, C; Reich N C. . J. Interferon Cytokine Res. (UNITED STATES). July 1999, 19 (7): 711–22. ISSN 1079-9907. PMID 10454341. doi:10.1089/107999099313550.

[pmid11574547-4] Litterst, C M; Pfitzner E. . J. Biol. Chem. (United States). Dec 2001, 276 (49): 45713–21. ISSN 0021-9258. PMID 11574547. doi:10.1074/jbc.M108132200.

[pmid9584180-5] Shen, C H; Stavnezer J. . Mol. Cell. Biol. (UNITED STATES). June 1998, 18 (6): 3395–404. ISSN 0270-7306. PMC 108921 . PMID 9584180.

[pmid12138096-6] Litterst, Claudia M; Pfitzner Edith. . J. Biol. Chem. (United States). September 2002, 277 (39): 36052–60. ISSN 0021-9258. PMID 12138096. doi:10.1074/jbc.M203556200.

[pmid10601358-7] Gupta, S; Jiang M; Anthony A; Pernis A B. . J. Exp. Med. (UNITED STATES). Dec 1999, 190 (12): 1837–48. ISSN 0022-1007. PMC 2195723 . PMID 10601358. doi:10.1084/jem.190.12.1837.

[pmid12234934-8] Yang, Jie; Aittomäki Saara; Pesu Marko; Carter Kara; Saarinen Jussi; Kalkkinen Nisse; Kieff Elliott; Silvennoinen Olli. . EMBO J. (England). September 2002, 21 (18): 4950–8. ISSN 0261-4189. PMC 126276 . PMID 12234934. doi:10.1093/emboj/cdf463.