P73

P73
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	4GUQ、1COK、1DXS、2KBY、2MPS、2WQI、2WQJ、2WTT、2XWC、3VD0、3VD1、3VD2、4A63、4G82、4G83、4GUO
识别号
别名	TP73；, P73, tumor protein p73, CILD47
外部ID	OMIM：601990 MGI：1336991 HomoloGene：3960 GeneCards：TP73
基因位置（人类）
染色体	1号染色体[1]
终止	3,736,201 bp[1]
基因位置（小鼠）
染色体	小鼠4号染色体[2]
终止	154,224,665 bp[2]
RNA表达模式
	查阅更多表达数据
基因本体
分子功能	• DNA结合; • sequence-specific DNA binding; • DNA-binding transcription activator activity, RNA polymerase II-specific; • 转录因子结合; • chromatin binding; • 金属离子结合; • RNA polymerase II cis-regulatory region sequence-specific DNA binding; • damaged DNA binding; • 血浆蛋白结合; • 相同蛋白质结合; • protein kinase binding; • p53 binding; • DNA结合转录因子活性; • MDM2/MDM4 family protein binding; • DNA-binding transcription factor activity, RNA polymerase II-specific;
细胞组分	• 细胞质; • 高尔基体; • 细胞内膜结合细胞器; • 转录调节复合物; • 细胞连接; • 染色质; • 细胞核; • 线粒体; • 核质; • 细胞质基质;
生物学过程	• negative regulation of neuron apoptotic process; • positive regulation of oligodendrocyte differentiation; • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; • regulation of transcription, DNA-templated; • negative regulation of neuron differentiation; • 肾的发生; • cellular response to UV; • negative regulation of transcription by RNA polymerase II; • protein tetramerization; • transcription, DNA-templated; • cellular response to DNA damage stimulus; • mitotic G1 DNA damage checkpoint signaling; • response to organonitrogen compound; • intrinsic apoptotic signaling pathway in response to DNA damage; • regulation of mitotic cell cycle; • positive regulation of apoptotic process; • 基因调节; • DNA错配修复; • 细胞周期; • negative regulation of cardiac muscle cell proliferation; • viral process; • negative regulation of JUN kinase activity; • response to gamma radiation; • response to X-ray; • positive regulation of transcription by RNA polymerase II; • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; • negative regulation of cell population proliferation; • 细胞凋亡; • regulation of signal transduction by p53 class mediator; • transcription by RNA polymerase II; • regulation of apoptotic process; • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; • positive regulation of transcription, DNA-templated; • regulation of hematopoietic stem cell differentiation;
	Sources:Amigo / QuickGO
直系同源
	7161
	22062
	ENSG00000078900
	ENSMUSG00000029026
	O15350
	Q9JJP2
NM_001126240; NM_001126241; NM_001126242; NM_001204184; NM_001204185;
	NM_001204186; NM_001204187; NM_001204188; NM_001204189; NM_001204190; NM_001204191; NM_001204192; NM_005427
	NM_001126330; NM_001126331; NM_011642
NP_001119712; NP_001119713; NP_001119714; NP_001191113; NP_001191114;
	NP_001191115; NP_001191116; NP_001191117; NP_001191118; NP_001191119; NP_001191120; NP_001191121; NP_005418
	NP_001119802; NP_001119803; NP_035772
	维基数据

p73，又称为TP73，是p53蛋白家族的成员之一，以其分子量为73kD而得名，存在多种转录变体。p73的结构和功能均与p53类似，为肿瘤抑制蛋白，能调控细胞增殖并促进细胞凋亡。过表达p73的细胞增殖会停止。

参见

p53
p63

参考文献

GRCh38: Ensembl release 89: ENSG00000078900 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000029026 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000078900 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029026 - Ensembl, May 2017

[3] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.