Oct4

Oct4
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1OCP、3L1P
識別號
别名	POU5F1；, OCT3, OCT4, OTF-3, OTF3, OTF4, Oct-3, Oct-4, POU class 5 homeobox 1, Oct3/4
外部ID	OMIM：164177 MGI：101893 HomoloGene：8422 GeneCards：POU5F1
相關疾病
	史蒂芬斯－強森症候群[1]
基因位置（人类）
染色体	6號染色體[2]
终止	31,180,731 bp[2]
基因位置（小鼠）
染色体	小鼠17号染色体[3]
终止	35,821,669 bp[3]
RNA表达模式
	; ; ; ;
	查阅更多表达数据
基因本體
分子功能	• DNA结合; • sequence-specific DNA binding; • miRNA binding; • DNA结合转录因子活性; • 转录因子结合; • transcription cis-regulatory region binding; • 血浆蛋白结合; • DNA结合转录阻遏物活性，RNA聚合酶II特异性; • DNA-binding transcription factor activity, RNA polymerase II-specific; • 泛素蛋白连接酶结合; • RNA binding;
細胞組分	• 細胞質; • 细胞质基质; • 轉錄調節複合物; • 核质; • 细胞核; • 線粒體;
生物學過程	• regulation of transcription, DNA-templated; • somatic stem cell population maintenance; • negative regulation of gene silencing by miRNA; • cell fate commitment involved in formation of primary germ layer; • endodermal cell fate specification; • anatomical structure morphogenesis; • mRNA transcription by RNA polymerase II; • regulation of asymmetric cell division; • negative regulation of transcription by RNA polymerase II; • transcription by RNA polymerase II; • transcription, DNA-templated; • regulation of DNA methylation-dependent heterochromatin assembly; • multicellular organism development; • cardiac cell fate determination; • response to wounding; • BMP signaling pathway involved in heart induction; • 基因調節; • regulation of heart induction by regulation of canonical Wnt signaling pathway; • blastocyst development; • positive regulation of transcription by RNA polymerase II; • positive regulation of SMAD protein signal transduction;
	Sources:Amigo / QuickGO
直系同源
	5460
	18999
ENSG00000230336; ENSG00000206454; ENSG00000204531; ENSG00000237582; ENSG00000229094;
	ENSG00000233911; ENSG00000235068
	ENSMUSG00000024406
	Q01860
	P20263
	NM_203289; NM_001173531; NM_001285986; NM_001285987; NM_002701
	NM_001252452; NM_013633
NP_001167002; NP_001272915; NP_001272916; NP_002692; NP_976034;
	NP_001272915.1
	NP_001239381; NP_038661
	維基數據

Oct4（八聚體結合轉錄因子4, octamer-binding transcription factor 4）,亦稱爲POU5F1（第五類POU結構域轉錄因子1），是一種蛋白質，在人體中由POU5F1基因編碼[6]。Oct4是一種具有與POU結構域同源的結構域的轉錄因子。Oct4對未分化的胚胎幹細胞的自我更新與幹性維持至關重要[7]。也正因如此，有時Oct4會被用來作標記未分化細胞的分子標記。Oct4的過表達或低表達都會造成細胞的分化，因此Oct4只在特定的表達強度下才能維持細胞的幹性[8]。

Oct4（八聚體結合轉錄因子4）名稱中的「八聚體」（octamer）指DNA核苷酸序列「A TTTG CAT」[9]。

參見

Sox2
Nanog

參考

.
GRCh38: Ensembl release 89: ENSG00000230336、ENSG00000206454、ENSG00000204531、ENSG00000237582、ENSG00000229094、ENSG00000233911、ENSG00000235068 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000024406 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
Takeda J, Seino S, Bell GI. . Nucleic Acids Research. Sep 1992, 20 (17): 4613–20. PMC 334192 . PMID 1408763. doi:10.1093/nar/20.17.4613.
Young Lab- Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells （页面存档备份，存于） at MIT
Niwa H, Miyazaki J, Smith AG. . Nature Genetics. Apr 2000, 24 (4): 372–6. PMID 10742100. doi:10.1038/74199.
Petryniak B, Staudt LM, Postema CE, McCormack WT, Thompson CB. . Proceedings of the National Academy of Sciences of the United States of America. Feb 1990, 87 (3): 1099–103. PMC 53418 . PMID 1967834. doi:10.1073/pnas.87.3.1099.

拓展閱讀

Lamoury FM, Croitoru-Lamoury J, Brew BJ. . Cytotherapy. 2006, 8 (3): 228–42. PMID 16793732. doi:10.1080/14653240600735875.
Hough SR, Clements I, Welch PJ, Wiederholt KA. . Stem Cells. Jun 2006, 24 (6): 1467–75. PMID 16456133. doi:10.1634/stemcells.2005-0475.
Feldman N, Gerson A, Fang J, Li E, Zhang Y, Shinkai Y, Cedar H, Bergman Y. . Nature Cell Biology. Feb 2006, 8 (2): 188–94. PMID 16415856. doi:10.1038/ncb1353.
Boyer LA, Lee TI, Cole MF, Johnstone SE, Levine SS, Zucker JP, Guenther MG, Kumar RM, Murray HL, Jenner RG, Gifford DK, Melton DA, Jaenisch R, Young RA. . Cell. Sep 2005, 122 (6): 947–56. PMC 3006442 . PMID 16153702. doi:10.1016/j.cell.2005.08.020.
Gerrard L, Zhao D, Clark AJ, Cui W. . Stem Cells. 2005, 23 (1): 124–33. PMID 15625129. doi:10.1634/stemcells.2004-0102.
Reményi A, Lins K, Nissen LJ, Reinbold R, Schöler HR, Wilmanns M. . Genes & Development. Aug 2003, 17 (16): 2048–59. PMC 196258 . PMID 12923055. doi:10.1101/gad.269303.
Schoorlemmer J, Kruijer W. . Mechanisms of Development. Dec 1991, 36 (1-2): 75–86. PMID 1723621. doi:10.1016/0925-4773(91)90074-G.
Wey E, Lyons GE, Schäfer BW. . European Journal of Biochemistry / FEBS. Mar 1994, 220 (3): 753–62. PMID 7908264. doi:10.1111/j.1432-1033.1994.tb18676.x.
Crouau-Roy B, Amadou C, Bouissou C, Clayton J, Vernet C, Ribouchon MT, Pontarotti P. . Genomics. May 1994, 21 (1): 241–3. PMID 8088794. doi:10.1006/geno.1994.1249.
Guillaudeux T, Mattei MG, Depetris D, Le Bouteiller P, Pontarotti P. . Cytogenetics and Cell Genetics. 1993, 63 (4): 212–4. PMID 8500351. doi:10.1159/000133537.
Abdel-Rahman B, Fiddler M, Rappolee D, Pergament E. . Human Reproduction. Oct 1995, 10 (10): 2787–92. PMID 8567814.
Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M. . Genome Research. Sep 1996, 6 (9): 807–28. PMID 8889549. doi:10.1101/gr.6.9.807.
Inamoto S, Segil N, Pan ZQ, Kimura M, Roeder RG. . The Journal of Biological Chemistry. Nov 1997, 272 (47): 29852–8. PMID 9368058. doi:10.1074/jbc.272.47.29852.
Nichols J, Zevnik B, Anastassiadis K, Niwa H, Klewe-Nebenius D, Chambers I, Schöler H, Smith A. . Cell. Oct 1998, 95 (3): 379–91. PMID 9814708. doi:10.1016/S0092-8674(00)81769-9.
Gonzalez MI, Robins DM. . The Journal of Biological Chemistry. Mar 2001, 276 (9): 6420–8. PMID 11096094. doi:10.1074/jbc.M008689200.
Butteroni C, De Felici M, Schöler HR, Pesce M. . Journal of Molecular Biology. Dec 2000, 304 (4): 529–40. PMID 11099378. doi:10.1006/jmbi.2000.4238.
Ezashi T, Ghosh D, Roberts RM. . Molecular and Cellular Biology. Dec 2001, 21 (23): 7883–91. PMC 99954 . PMID 11689681. doi:10.1128/MCB.21.23.7883-7891.2001.
Guo Y, Costa R, Ramsey H, Starnes T, Vance G, Robertson K, Kelley M, Reinbold R, Scholer H, Hromas R. . Proceedings of the National Academy of Sciences of the United States of America. Mar 2002, 99 (6): 3663–7. PMC 122580 . PMID 11891324. doi:10.1073/pnas.062041099.
Looijenga LH, Stoop H, de Leeuw HP, de Gouveia Brazao CA, Gillis AJ, van Roozendaal KE, van Zoelen EJ, Weber RF, Wolffenbuttel KP, van Dekken H, Honecker F, Bokemeyer C, Perlman EJ, Schneider DT, Kononen J, Sauter G, Oosterhuis JW. . Cancer Research. May 2003, 63 (9): 2244–50. PMID 12727846.
Wang P, Branch DR, Bali M, Schultz GA, Goss PE, Jin T. . The Biochemical Journal. Oct 2003, 375 (Pt 1): 199–205. PMC 1223663 . PMID 12841847. doi:10.1042/BJ20030579.
Reményi A, Lins K, Nissen LJ, Reinbold R, Schöler HR, Wilmanns M. . Genes & Development. Aug 2003, 17 (16): 2048–59. PMC 196258 . PMID 12923055. doi:10.1101/gad.269303.
Rajpert-De Meyts E, Hanstein R, Jørgensen N, Graem N, Vogt PH, Skakkebaek NE. . Human Reproduction. Jun 2004, 19 (6): 1338–44. PMID 15105401. doi:10.1093/humrep/deh265.
Matin MM, Walsh JR, Gokhale PJ, Draper JS, Bahrami AR, Morton I, Moore HD, Andrews PW. . Stem Cells. 2005, 22 (5): 659–68. PMID 15342930. doi:10.1634/stemcells.22-5-659.
Baal N, Reisinger K, Jahr H, Bohle RM, Liang O, Münstedt K, Rao CV, Preissner KT, Zygmunt MT. . Thrombosis and Haemostasis. Oct 2004, 92 (4): 767–75. PMID 15467907. doi:10.1160/TH04-02-0079.

外部連結

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[1] .

[refGRCh38Ensembl-2] GRCh38: Ensembl release 89: ENSG00000230336、ENSG00000206454、ENSG00000204531、ENSG00000237582、ENSG00000229094、ENSG00000233911、ENSG00000235068 - Ensembl, May 2017

[refGRCm38Ensembl-3] GRCm38: Ensembl release 89: ENSMUSG00000024406 - Ensembl, May 2017

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1408763-6] Takeda J, Seino S, Bell GI. . Nucleic Acids Research. Sep 1992, 20 (17): 4613–20. PMC 334192 . PMID 1408763. doi:10.1093/nar/20.17.4613.

[7] Young Lab- Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells （页面存档备份，存于） at MIT

[pmid10742100-8] Niwa H, Miyazaki J, Smith AG. . Nature Genetics. Apr 2000, 24 (4): 372–6. PMID 10742100. doi:10.1038/74199.

[9] Petryniak B, Staudt LM, Postema CE, McCormack WT, Thompson CB. . Proceedings of the National Academy of Sciences of the United States of America. Feb 1990, 87 (3): 1099–103. PMC 53418 . PMID 1967834. doi:10.1073/pnas.87.3.1099.