NITD008

NITD008是一种抗病毒药物，属于腺苷类似物（一种核苷类似物）。它作为治疗黄病毒感染的潜在药物被开发，并显示出对很多相关病毒的广谱活性，如骨痛热症病毒、西尼羅河病毒、黄热病病毒、波瓦桑病毒、丙肝病毒、克亚萨努尔森林病病毒、鄂木斯克出血热病毒和茲卡病毒。[1][2][3]然而，虽然NITD008在临床前的动物试验中显示出较大毒性，不适合人体试验，但是它仍被用于新型病毒性疾病治疗的研究中。[4]

NITD008
臨床資料
商品名NITD008
识别
  • (2R,3R,4R,5R)-2-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3-ethynyl-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
CAS号1044589-82-3  checkY
PubChem CID
ChemSpider
UNII
ChEMBL
化学
化学式C13H14N4O4
摩尔质量290.28 g·mol−1
3D模型（JSmol）
  • C#C[C@]1([C@@H]([C@H](O[C@H]1N2C=CC3=C2N=CN=C3N)CO)O)O
  • InChI=1S/C13H14N4O4/c1-2-13(20)9(19)8(5-18)21-12(13)17-4-3-7-10(14)15-6-16-11(7)17/h1,3-4,6,8-9,12,18-20H,5H2,(H2,14,15,16)/t8-,9-,12-,13-/m1/s1
  • Key:NKRAIOQPSBRMOV-NRMKKVEVSA-N

参考文献
  1. Yin Z, Chen YL, Schul W, Wang QY, Gu F, Duraiswamy J, et al. . Proceedings of the National Academy of Sciences of the United States of America. December 2009, 106 (48): 20435–9. Bibcode:2009PNAS..10620435Y. PMC 2787148 可免费查阅. PMID 19918064. doi:10.1073/pnas.0907010106 可免费查阅.
  2. Lo MK, Shi PY, Chen YL, Flint M, Spiropoulou CF. . Antiviral Research. June 2016, 130: 46–9. PMC 5096641 可免费查阅. PMID 27016316. doi:10.1016/j.antiviral.2016.03.013.
  3. Deng YQ, Zhang NN, Li CF, Tian M, Hao JN, Xie XP, et al. . Open Forum Infectious Diseases. October 2016, 3 (4): ofw175. PMC 5063548 可免费查阅. PMID 27747251. doi:10.1093/ofid/ofw175 可免费查阅.
  4. Nelson J, Roe K, Orillo B, Shi PY, Verma S. . Antiviral Research. October 2015, 122: 39–45. PMC 4853296 可免费查阅. PMID 26225754. doi:10.1016/j.antiviral.2015.07.008.
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