METTL3

METTL3
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	5IL0、5IL2、5IL1、5K7M、5K7U、5K7W
識別號
别名	METTL3；, IME4, M6A, MT-A70, Spo8, methyltransferase like 3, hmethyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit
外部ID	OMIM：612472 MGI：1927165 HomoloGene：10501 GeneCards：METTL3
基因位置（人类）
染色体	14號染色體[1]
终止	21,511,342 bp[1]
基因位置（小鼠）
染色体	小鼠14号染色体[2]
终止	52,542,585 bp[2]
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• methyltransferase activity; • 轉移酶活性; • RNA binding; • RNA methyltransferase activity; • mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity; • mRNA binding; • S-adenosyl-L-methionine binding; • protein heterodimerization activity; • 血浆蛋白结合; • mRNA (N6-adenosine)-methyltransferase activity;
細胞組分	• RNA N6-methyladenosine methyltransferase complex; • 核质; • nuclear speck; • 细胞核; • 細胞質;
生物學過程	• rhythmic process; • mRNA processing; • positive regulation of cap-independent translational initiation; • stem cell population maintenance; • 甲基化; • mRNA methylation; • mRNA destabilization; • 昼夜节律; • primary miRNA processing; • adenosine to inosine editing; • RNA甲基化; • mRNA splicing, via spliceosome; • mRNA catabolic process; • forebrain radial glial cell differentiation; • cellular response to UV; • gliogenesis; • regulation of T cell differentiation; • negative regulation of Notch signaling pathway; • regulation of meiotic cell cycle; • endothelial to hematopoietic transition; • regulation of hematopoietic stem cell differentiation; • cellular response to DNA damage stimulus; • 精子发生; • 细胞分化; • dosage compensation by inactivation of X chromosome; • 核糖核酸代谢过程;
	Sources:Amigo / QuickGO
直系同源
	56339
	56335
	ENSG00000165819
	ENSMUSG00000022160
	Q86U44
	Q8C3P7
	NM_019852
	NM_019721
	NP_062826
	NP_062695
	維基數據

METTL3全稱為甲基转移酶样蛋白3（methyltransferase like 3），又稱N6-腺苷甲基转移酶複合體催化亞基（N6-adenosine-methyltransferase complex catalytic subunit），在人類基因組中由14號染色體上的METTL3基因編碼[5]。此蛋白為N6-腺苷甲基转移酶複合體中具甲基轉移酶活性的組成蛋白，由580個氨基酸組成，大小為70kDa，包含一鋅指結構域與一甲基轉移酶結構域，可將S-腺苷甲硫氨酸（SAM）上的甲基轉移到mRNA中的腺苷（A）上，將其甲基化成N6-甲基腺苷（m⁶A）[5][6]。METTL3與另一蛋白METTL14共同組成N6-腺苷甲基转移酶複合體的核心，但METTL14在此複合體中僅有與RNA結合和穩定結構的功能，無催化甲基化的功能。METTL3的基因表現異常與多種癌症有關，許多案例中METTL3為致癌基因，在許多癌症中表現量增加[6]。

參考文獻

GRCh38: Ensembl release 89: ENSG00000165819 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000022160 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
.
Zeng C, Huang W, Li Y, Weng H. . J Hematol Oncol. 2020, 13 (1): 117. PMC 7457244 . PMID 32854717. doi:10.1186/s13045-020-00951-w.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000165819 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022160 - Ensembl, May 2017

[3] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] .

[pmid32854717-6] Zeng C, Huang W, Li Y, Weng H. . J Hematol Oncol. 2020, 13 (1): 117. PMC 7457244 . PMID 32854717. doi:10.1186/s13045-020-00951-w.