JWH大麻素列表

克莱门森大学的约翰·威廉·霍夫曼（John William Huffman）研究小组合成了450多种大麻素[1][2]。其中一些是[3][4]：

大麻素及其Ki值[lower-alpha 1]
名称 类别 分子式 Ki/nM (CB1) Ki/nM (CB2) 选择性 结构
JWH-004 萘甲酰基吲哚 C26H27NO 48 ± 13 4 ± 1.5 CB2 (12x)
JWH-007[5] 萘甲酰基吲哚 C25H25NO 9.5 ± 4.5 2.9 ± 2.6 CB2 (3.3x)
JWH-009 萘甲酰基吲哚 C27H29NO >10000 141 ± 14 CB2 (>70x)
JWH-011 萘甲酰基吲哚 C27H29NO
JWH-015[5] 萘甲酰基吲哚 C23H21NO 164 ± 22 13.8 ± 4.6 CB2 (12x)
JWH-016 萘甲酰基吲哚 C24H23NO 22 ± 1.5 4.3 ± 1.6 CB2 (5.1x)
JWH-018[5] 萘甲酰基吲哚 C24H23NO 9 ± 5 2.9 ± 2.6 CB2 (3.1x)
JWH-019 萘甲酰基吲哚 C25H25NO 9.8 ± 2 5.55 ± 2 CB2 (1.77x)
JWH-020 萘甲酰基吲哚 C26H27NO 128 ± 17 205 ± 20 CB1 (1.6x)
JWH-030 萘甲酰基吡咯 C20H21NO 87 ± 3 320 ± 127 CB1 (3.7x)
JWH-031 萘甲酰基吡咯 C21H23NO 399 ± 109
JWH-032 萘甲酰基吡咯 C18H17NO >10000 >10000 —
JWH-033 萘甲酰基吡咯 C19H19NO 666 ± 77
JWH-036 萘甲酰基吡咯 C22H25NO 309 ± 11
JWH-042[6] 萘甲酰基吲哚 C21H17NO >10000 5050 ± 192 CB2
JWH-043[6] 萘甲酰基吲哚 C22H19NO 1180 ± 44 964 ± 242 CB2 (1.2x)
JWH-044 萘甲酰基吡咯 C16H13NO >10000 >10000 —
JWH-045 萘甲酰基吡咯 C17H15NO >10000 >10000 —
JWH-046[6] 萘甲酰基吲哚 C24H23NO 343 ± 38 16.3 ± 4.9 CB2 (21x)
JWH-047[6] 萘甲酰基吲哚 C25H25NO 59 ± 3 3.47 ± 1.80 CB2 (17x)
JWH-048[6] 萘甲酰基吲哚 C26H27NO 10.7 ± 1.0 0.49 ± 0.13 CB2 (22x)
JWH-049[6] 萘甲酰基吲哚 C27H29NO 55.1 ± 17.0 32.3 ± 2.4 CB2 (1.7x)
JWH-050[6] 萘甲酰基吲哚 C28H31NO 342 ± 6 526 ± 133 CB1 (1.5x)
JWH-051 二苯并吡喃 C25H38O2 1.20 0.03 CB2 (40x)
JWH-056[7] 二苯并吡喃 C21H30O >10000 32 ± 9 CB2
JWH-057[8] 二苯并吡喃 C25H38O 23 ± 7 2.9 ± 1.6 CB2 (8x)
JWH-065[7] 二苯并吡喃 C23H34O 399 ± 76 10 ± 2 CB2 (40x)
JWH-070[6] 萘甲酰基吲哚 C20H15NO >10000 >10000
JWH-071[6] 萘甲酰基吲哚 C21H17NO 1340 ± 123 2940 ± 852 CB1 (2.2x)
JWH-072 萘甲酰基吲哚 C22H19NO 1050 ± 5.5 170 ± 54 CB2 (6x)
JWH-073 萘甲酰基吲哚 C23H21NO 8.9 ± 1.8 27 ± 12 CB1 (3x)
JWH-076[5] 萘甲酰基吲哚 C23H21NO 214 ± 11 106 ± 46 CB2 (2x)
JWH-077[6] 萘甲酰基吲哚 C21H17NO2 >10000 >10000
JWH-078[6] 萘甲酰基吲哚 C22H19NO2 817 ± 60 633 ± 116 CB2 (1.3x)
JWH-079[6] 萘甲酰基吲哚 C23H21NO2 63.0 ± 3.0 32.0 ± 6.0 CB2 (2x)
JWH-080[6] 萘甲酰基吲哚 C24H23NO2 8.9 ± 1.8 2.21 ± 1.30 CB2 (4x)
JWH-081[6] 萘甲酰基吲哚 C25H25NO2 1.2 ± 0.03 12.4 ± 2.2 CB1 (10x)
JWH-082[6] 萘甲酰基吲哚 C26H27NO2 5.3 ± 0.8 6.40 ± 0.94 CB1 (1.2x)
JWH-083[6] 萘甲酰基吲哚 C27H29NO2 106 ± 12 102 ± 50 —
JWH-091[9] (Δ8-THCP) 二苯并吡喃 C23H34O2 22.0 ± 3.9
JWH-093[6] 萘甲酰基吲哚 C27H29NO2 40.7 ± 2.8 59.1 ± 10.5 CB1 (1.45x)
JWH-094[6] 萘甲酰基吲哚 C24H23NO2 476 ± 67 97.3 ± 2.7 CB2 (4.9x)
JWH-095[6] 萘甲酰基吲哚 C29H33NO2 140 ± 4.3 312 ± 83 CB1 (2.2x)
JWH-096[6] 萘甲酰基吲哚 C25H25NO2 33.7 ± 2.9 13.3 ± 5.6 CB2 (2.5x)
JWH-097[6] 萘甲酰基吲哚 C31H37NO2 455 ± 28 121 ± 15 CB2 (3.8x)
JWH-098[6] 萘甲酰基吲哚 C26H27NO2 4.5 ± 0.1 1.9 ± 0.3 CB2 (2.4x)
JWH-099[6] 萘甲酰基吲哚 C27H29NO2 35.3 ± 9.0 17.8 ± 2.9 CB2 (2x)
JWH-100[6] 萘甲酰基吲哚 C25H38O2 381 ± 102 155 ± 74 CB2 (2.5x)
JWH-102[7] 二苯并吡喃 C24H38O2 7.9 ± 0.9 5.2 ± 2.0 CB2 (1.5x)
JWH-103[7] 二苯并吡喃 C24H38O2 28 ± 3 23 ± 7 CB2 (1.2x)
JWH-116[10] 萘甲酰基吲哚 C26H27NO 52 ± 5
JWH-120[5] 萘甲酰基吲哚 C23H21NO 1054 ± 31 6.1 ± 0.7 CB2 (173x)
JWH-121 萘甲酰基吲哚 C24H23NO —
JWH-122[10] 萘甲酰基吲哚 C25H25NO 0.69 ± 0.05 1.2 ± 1.2 —
JWH-124 (Δ8-Parahexyl) 二苯并吡喃 C22H32O2 41.0 ± 3.8
JWH-130 (Δ8-THCB) 二苯并吡喃 C20H28O2 65.0 ± 13
JWH-133[7] 二苯并吡喃 C22H32O 677 ± 132 3.4 ± 1.0 CB2 (200x)
JWH-138[11] 二苯并吡喃 C24H36O2 8.5 ± 1.4
JWH-139[12] 二苯并吡喃 C21H30O 2290 ± 505 14 ± 10 CB2 (164x)
JWH-142[7] 二苯并吡喃 C26H40O2 529 ± 49 35 ± 14 CB2 (15x)
JWH-143[7] 二苯并吡喃 C26H40O2 924 ± 104 65 ± 8 CB2 (14x)
JWH-145[13] 萘甲酰基吡咯 C26H25NO 14 ± 2 6.4 ± 0.4 CB2 (2.2x)
JWH-146[13] 萘甲酰基吡咯 C28H29NO 21 ± 2 62 ± 5 CB2 (3.0x)
JWH-147[13] 萘甲酰基吡咯 C27H27NO 11 ± 1 7.1 ± 0.2 CB2 (1.5x)
JWH-148[5] 萘甲酰基吲哚 C24H23NO 123 ± 8 14.0 ± 1.0 CB2 (8x)
JWH-149[5] 萘甲酰基吲哚 C26H27NO 5.0 ± 2.1 0.73 ± 0.03 CB2 (6.8x)
JWH-150[13] 萘甲酰基吡咯 C25H23NO 60 ± 1 15 ± 2 CB2 (4x)
JWH-151[5] 萘甲酰基吲哚 C24H23NO2 >10000 30 ± 1.1 CB2 (>333x)
JWH-153[5] 萘甲酰基吲哚 C26H27NO2 250 ± 24 11 ± 0.5 CB2 (23x)
JWH-156[13] 萘甲酰基吡咯 C24H21NO 404 ± 18 104 ± 18 CB2 (4x)
JWH-159[5] 萘甲酰基吲哚 C26H27NO2 45 ± 1 10.4 ± 1.4 CB2 (4.3x)
JWH-160[5] 萘甲酰基吲哚 C24H23NO2 1568 ± 201 441 ± 110 CB2 (3.6x)
JWH-161 二苯并吡喃合体 19.0
JWH-163[5] 萘甲酰基吲哚 C23H21NO2 2358 ± 215 138 ± 12 CB2 (17x)
JWH-164[5] 萘甲酰基吲哚 C25H25NO2 6.6 ± 0.7 6.9 ± 0.2 —
JWH-165[5] 萘甲酰基吲哚 C23H21NO2 204 ± 26 71 ± 8 CB2 (2.9x)
JWH-166[5] 萘甲酰基吲哚 C25H25NO2 44 ± 10 1.9 ± 0.08 CB2 (23x)
JWH-167 苯乙酰吲哚 C21H23NO 90 ± 17 159 ± 14 CB1 (1.77x)
JWH-171 碳氢 51
JWH-175[10] 萘甲基吲哚 22 ± 2
JWH-176[10] 碳氢 26 ± 4
JWH-180[5] 萘甲酰基吲哚 C25H25NO 26 ± 2 9.6 ± 2.0 CB2 (2.7x)
JWH-181[5] 萘甲酰基吲哚 C28H31NO 1.3 ± 0.1 0.62 ± 0.04 CB2 (2.1x)
JWH-182[5] 萘甲酰基吲哚 C27H29NO 0.65 ± 0.03 1.1 ± 0.1 CB1 (1.7x)
JWH-184[10] 萘甲基吲哚 23 ± 6
JWH-185[10] 萘甲基吲哚 17 ± 3
JWH-186[14] 二苯并吡喃 187 ± 23 5.6 ± 1.7 CB2 (33x)
JWH-187[14] 二苯并吡喃 84 ± 16 3.4 ± 0.5 CB2 (25x)
JWH-188[14] 二苯并吡喃 270 ± 58 18 ± 2 CB2 (15x)
JWH-189[5] 萘甲酰基吲哚 C26H27NO 52 ± 2 12 ± 0.8 CB2 (4.3x)
JWH-190[14] 二苯并吡喃 8.8 ± 1.4 1.6 ± 0.03 CB2 (5.5x)
JWH-191[14] 二苯并吡喃 1.8 ± 0.3 0.52 ± 0.03 CB2 (3.5x)
JWH-192[10] 萘甲基吲哚 41 ± 13
JWH-193[10] 萘甲酰基吲哚 6 ± 1
JWH-194[10] 萘甲基吲哚 127 ± 19
JWH-195[10] 萘甲基吲哚 113 ± 28
JWH-196[10] 萘甲基吲哚 151 ± 18
JWH-197[10] 萘甲基吲哚 323 ± 98
JWH-198[10] 萘甲酰基吲哚 10 ± 2
JWH-199[10] 萘甲基吲哚 20 ± 2
JWH-200[10] 萘甲酰基吲哚 C25H24N2O2 42 ± 5
JWH-201[15] 苯乙酰吲哚 C22H25NO2 1064 ± 21 444 ± 14 CB2 (2.4x)
JWH-202[15] 苯乙酰吲哚 C23H27NO2 1678 ± 63 645 ± 6 CB2 (2.6x)
JWH-203[15] 苯乙酰吲哚 8.0 ± 0.9 7.0 ± 1.3 —
JWH-204[15] 苯乙酰吲哚 13 ± 1 25 ± 1 CB1 (1.9x)
JWH-205[15] 苯乙酰吲哚 C22H25NO 124 ± 23 180 ± 9 CB1 (1.45x)
JWH-206[15] 苯乙酰吲哚 389 ± 25 498 ± 37 CB1 (1.28x)
JWH-207[15] 苯乙酰吲哚 1598 ± 134 3723 ± 10 CB1 (2.33x)
JWH-208[15] 苯乙酰吲哚 C22H25NO 179 ± 7 570 ± 127 CB1 (3.18x)
JWH-209[15] 苯乙酰吲哚 C23H27NO 746 ± 49 1353 ± 270 CB1 (1.81x)
JWH-210[5] 萘甲酰基吲哚 C26H27NO 0.46 ± 0.03 0.69 ± 0.01 CB1 (1.5x)
JWH-211[5] 萘甲酰基吲哚 C25H25NO 70 ± 0.8 12 ± 0.8 CB2 (5.8x)
JWH-212[5] 萘甲酰基吲哚 C24H23NO 33 ± 0.9 10 ± 1.2 CB2 (3.3x)
JWH-213[5] 萘甲酰基吲哚 C27H29NO 1.5 ± 0.2 0.42 ± 0.05 CB2 (3.6x)
JWH-215[14] 二苯并吡喃 1008 ± 117 85 ± 21 CB2 (12x)
JWH-216[14] 二苯并吡喃 1856 ± 148 333 ± 104 CB2 (5.6x)
JWH-217[14] 二苯并吡喃 >10000 1404 ± 66 CB2 (>7x)
JWH-220 碳氢 19
JWH-224[14] 二苯并吡喃 347 ± 34 28 ± 1 CB2 (12.3x)
JWH-225[14] 二苯并吡喃 >10000 325 ± 70 CB2 (>31x)
JWH-226[14] 二苯并吡喃 4001 ± 282 43 ± 3 CB2 (93x)
JWH-227[14] 二苯并吡喃 40 ± 6 4.4 ± 0.3 CB2 (9x)
JWH-229[16] 二苯并吡喃 3134 ± 110 18 ± 2 CB2 (174x)
JWH-230[14] 二苯并吡喃 15 ± 3 1.4 ± 0.12 CB2 (10.7x)
JWH-233[14] 二苯并吡喃 14 ± 3 1.0 ± 0.3 CB2 (14x)
JWH-234[5] 萘甲酰基吲哚 C26H27NO 8.4 ± 1.8 3.8 ± 0.6 CB2 (2.2x)
JWH-235[5] 萘甲酰基吲哚 C24H23NO 338 ± 34 123 ± 34 CB2 (2.7x)
JWH-236[5] 萘甲酰基吲哚 C25H25NO 1351 ± 204 240 ± 63 CB2 (5.6x)
JWH-237[15] 苯乙酰吲哚 38 ± 10 106 ± 2 CB1 (2.8x)
JWH-239[5] 萘甲酰基吲哚 C26H27NO 342 ± 20 52 ± 6 CB2 (6.6x)
JWH-240[5] 萘甲酰基吲哚 C28H31NO 14 ± 1 7.2 ± 1.3 CB2 (1.9x)
JWH-241[5] 萘甲酰基吲哚 C27H29NO 147 ± 20 49 ± 7 CB2 (3.0x)
JWH-242[5] 萘甲酰基吲哚 C29H33NO 42 ± 9 6.5 ± 0.3 CB2 (6.5x)
JWH-243[13] 萘甲酰基吡咯 285 ± 40 41 ± 3 CB2 (6.95x)
JWH-244[13] 萘甲酰基吡咯 130 ± 6 18 ± 1 CB2 (7.22x)
JWH-245[13] 萘甲酰基吡咯 276 ± 4 25 ± 2 CB2 (11x)
JWH-246[13] 萘甲酰基吡咯 70 ± 4 16 ± 1 CB2 (4.38x)
JWH-247[14] 二苯并吡喃 427 ± 31 99 ± 4 CB2 (4.3x)
JWH-248[15] 苯乙酰吲哚 1028 ± 39 657 ± 19 CB2 (1.56x)
JWH-249[15] 苯乙酰吲哚 8.4 ± 1.8 20 ± 2 CB1 (2.38x)
JWH-250[15] 苯乙酰吲哚 C22H25NO2 11 ± 2 33 ± 2 CB1 (3x)
JWH-251[15] 苯乙酰吲哚 C22H25NO 29 ± 3 146 ± 36 CB2 (5x)
JWH-252[15] 苯乙酰吲哚 C23H27NO 23 ± 3 19 ± 1 CB2 (1.2x)
JWH-253[15] 苯乙酰吲哚 C23H27NO2 62 ± 10 84 ± 12 CB1 (1.35x)
JWH-254[14] 二苯并吡喃 4724 ± 509 319 ± 16 CB2 (14.8x)
JWH-256[14] 二苯并吡喃 4300 ± 888 97 ± 18 CB2 (44x)
JWH-258[5] 萘甲酰基吲哚 C26H27NO2 4.6 ± 0.6 10.5 ± 1.3 CB1 (2.3x)
JWH-259[5] 萘甲酰基吲哚 C24H23NO2 220 ± 29 74 ± 7 CB2 (3.0x)
JWH-260[5] 萘甲酰基吲哚 C27H29NO2 29 ± 0.4 25 ± 1.9 CB2 (1.2x)
JWH-261[5] 萘甲酰基吲哚 C25H25NO2 767 ± 105 221 ± 14 CB2 (3.5x)
JWH-262[5] 萘甲酰基吲哚 C27H29NO 28 ± 3 5.6 ± 0.7 CB2 (5.0x)
JWH-265[5] 萘甲酰基吲哚 C23H21NO2 3788 ± 323 80 ± 13 CB2 (47x)
JWH-266[5] 萘甲酰基吲哚 C24H23NO2 >10000 455 ± 55 CB2 (>22x)
JWH-267[5] 萘甲酰基吲哚 C25H25NO2 381 ± 16 7.2 ± 0.14 CB2 (53x)
JWH-268[5] 萘甲酰基吲哚 C26H27NO2 1379 ± 193 40 ± 0.6 CB2 (34x)
JWH-277[14] 二苯并吡喃 3905 ± 91 589 ± 65 CB2 (6.6x)
JWH-278[14] 二苯并吡喃 906 ± 80 69 ± 6 CB2 (13x)
JWH-292[13] 萘甲酰基吡咯 29 ± 1 20 ± 1 CB2 (1.45x)
JWH-293[13] 萘甲酰基吡咯 100 ± 5 41 ± 4 CB2 (2.44x)
JWH-298[14] 二苯并吡喃 812 ± 67 198 ± 23 CB2 (4.1x)
JWH-299[14] 二苯并吡喃 415 ± 50 30 ± 2 CB2 (13.8x)
JWH-300[12] 二苯并吡喃 118 ± 16 5.3 ± 0.1 CB2 (22x)
JWH-301[14] 二苯并吡喃 295 ± 64 48 ± 4 CB2 (6.1x)
JWH-302[15] 苯乙酰吲哚 C22H25NO2 17 ± 2 89 ± 15 CB1 (5.26x)
JWH-303[15] 苯乙酰吲哚 117 ± 10 138 ± 12 CB1 (1.18x)
JWH-304[15] 苯乙酰吲哚 3363 ± 332 2679 ± 688 CB2 (1.26x)
JWH-305[15] 苯乙酰吲哚 15 ± 1.8 29 ± 5 CB1 (1.93x)
JWH-306[15] 苯乙酰吲哚 C23H27NO2 25 ± 1 82 ± 11 CB1 (3.28x)
JWH-307[13] 萘甲酰基吡咯 7.7 ± 1.8 3.3 ± 0.2 CB2 (2.33x)
JWH-308[13] 萘甲酰基吡咯 41 ± 1 33 ± 2 CB2 (1.24x)
JWH-309[13] 萘甲酰基吡咯 41 ± 3 49 ± 7 CB1 (1.20x)
JWH-310[14] 二苯并吡喃 1059 ± 51 36 ± 3 CB2 (29x)
JWH-311[15] 苯乙酰吲哚 23 ± 2 39 ± 3 CB1 (1.70x)
JWH-312[15] 苯乙酰吲哚 72 ± 7 91 ± 20 CB1 (1.26x)
JWH-313[15] 苯乙酰吲哚 422 ± 19 365 ± 92 CB2 (1.16x)
JWH-314[15] 苯乙酰吲哚 39 ± 2 76 ± 4 CB1 (1.95x)
JWH-315[15] 苯乙酰吲哚 430 ± 24 182 ± 23 CB2 (3.36x)
JWH-316[15] 苯乙酰吲哚 2862 ± 670 781 ± 105 CB2 (3.66x)
JWH-336[12] 二苯并吡喃 4589 ± 367 153 ± 15 CB2 (30x)
JWH-338[14] 二苯并吡喃 >10000 111 ± 16 CB2 (>90x)
JWH-339[14] 二苯并吡喃 >10000 2317 ± 93 CB2 (>4.3x)
JWH-340[14] 二苯并吡喃 135 ± 6 30 ± 1 CB2 (4.5x)
JWH-341[14] 二苯并吡喃 100 ± 8 10 ± 0.1 CB2 (10x)
JWH-346[13] 萘甲酰基吡咯 67 ± 6 39 ± 2 CB2 (1.72x)
JWH-347[13] 萘甲酰基吡咯 333 ± 17 169 ± 17 CB2 (1.97x)
JWH-348[13] 萘甲酰基吡咯 218 ± 19 53 ± 1 CB2 (4.11x)
JWH-349[14] 二苯并吡喃 376 ± 1 38 ± 4 CB2 (9.9x)
JWH-350[12] 二苯并吡喃 395 ± 50 12 ± 1 CB2 (33x)
JWH-351[14] 二苯并吡喃 >10000 295 ± 3 CB2 (>34x)
JWH-352[14] 二苯并吡喃 >10000 47 ± 2 CB2 (>213x)
JWH-353[14] 二苯并吡喃 1493 ± 10 31 ± 1 CB2 (48x)
JWH-354[14] 二苯并吡喃 1961 ± 21 241 ± 14 CB2 (8.1x)
JWH-355[14] 二苯并吡喃 2162 ± 220 108 ± 17 CB2 (20x)
JWH-356[14] 二苯并吡喃 5837 ± 701 108 ± 17 CB2 (54x)
JWH-357[14] 二苯并吡喃 647 ± 78 185 ± 4 CB2 (3.5x)
JWH-358[14] 二苯并吡喃 1243 ± 266 52 ± 3 CB2 (24x)
JWH-359 二苯并吡喃 C24H36O2 2918 ± 450 13.0 ± 0.2 CB2 (220x)
JWH-360[14] 二苯并吡喃 2449 ± 606 160 ± 8 CB2 (15x)
JWH-361[14] 二苯并吡喃 63 ± 3 2.7 ± 0.1 CB2 (23x)
JWH-362[14] 二苯并吡喃 127 ± 8 34 ± 5 CB2 (3.7x)
JWH-363[13] 萘甲酰基吡咯 245 ± 5 71 ± 1 CB2 (3.45x)
JWH-364[13] 萘甲酰基吡咯 C28H29NO 34 ± 3 29 ± 1 CB2 (1.17x)
JWH-365[13] 萘甲酰基吡咯 C28H29NO 17 ± 1 3.4 ± 0.2 CB2 (5.0x)
JWH-366[13] 萘甲酰基吡咯 C25H24N2O 191 ± 12 24 ± 1 CB2 (7.96x)
JWH-367[13] 萘甲酰基吡咯 C27H27NO2 53 ± 2 23 ± 1 CB2 (2.30x)
JWH-368[13] 萘甲酰基吡咯 16 ± 1 9.1 ± 0.7 CB2 (1.76x)
JWH-369[13] 萘甲酰基吡咯 7.9 ± 0.4 5.2 ± 0.3 CB2 (1.52x)
JWH-370[13] 萘甲酰基吡咯 C27H27NO 5.6 ± 0.4 4.0 ± 0.5 CB2 (1.40x)
JWH-371[13] 萘甲酰基吡咯 C30H33NO 42 ± 1 64 ± 2 CB1 (1.52x)
JWH-372[13] 萘甲酰基吡咯 77 ± 2 8.2 ± 0.2 CB1 (9.39x)
JWH-373[13] 萘甲酰基吡咯 C30H33NO 60 ± 3 69 ± 2 CB1 (1.15x)
JWH-387[17] 萘甲酰基吲哚 C24H22BrNO 1.2 ± 0.1 1.1 ± 0.1 —
JWH-398[18] 萘甲酰基吲哚 2.3 ± 0.1 2.8 ± 0.2 CB1 (1.22x)
JWH-416[17] 萘甲酰基吲哚 73 ± 10 3.3 ± 0.1 CB2 (22x)
JWH-417[17] 萘甲酰基吲哚 522 ± 58 13 ± 0.2 CB2 (40x)
JWH-422[17] 萘甲酰基吲哚 501 ± 48 20 ± 0.4 CB2 (25x)
JWH-423[17] 萘甲酰基吲哚 140 ± 10 6.6 ± 0.2 CB2 (21x)
JWH-424[17] 萘甲酰基吲哚 C24H22BrNO 21 ± 3.4 5.4 ± 0.2 CB2 (3.9x)
JWH-425[17] 萘甲酰基吲哚 C25H24BrNO 54 ± 11 10 ± 0.4 CB2 (5.4x)

参见

注释
  1. Ki是化合物对大麻素1型受体（CB1）或大麻素2型受体（CB2）的结合亲和力

参考资料
  1. Manera C, Tuccinardi T, Martinelli A. . Mini Rev Med Chem. 2008, 8 (4): 370–87. PMID 18473928. doi:10.2174/138955708783955935.
  2. Wiley JL, Marusich JA, Huffman JW. . Life Sci. 2014, 97 (1): 55–63. PMC 3944940 可免费查阅. PMID 24071522. doi:10.1016/j.lfs.2013.09.011.
  3. Wiley JL, Marusich JA, Thomas BF. . Curr Top Behav Neurosci. Current Topics in Behavioral Neurosciences. 2017, 32: 231–248. ISBN 978-3-319-52442-9. PMID 27753007. doi:10.1007/7854_2016_17 可免费查阅.
  4. Banister SD, Connor M. . Handb Exp Pharmacol. Handbook of Experimental Pharmacology. 2018, 252: 165–190. ISBN 978-3-030-10560-0. PMID 29980914. doi:10.1007/164_2018_143.
  5. Huffman JW, Zengin G, Wu MJ, Lu J, Hynd G, Bushell K, Thompson AL, Bushell S, Tartal C, Hurst DP, Reggio PH, Selley DE, Cassidy MP, Wiley JL, Martin BR. . Bioorganic & Medicinal Chemistry. January 2005, 13 (1): 89–112. PMID 15582455. doi:10.1016/j.bmc.2004.09.050.
  6. Aung MM, Griffin G, Huffman JW, Wu M, Keel C, Yang B, Showalter VM, Abood ME, Martin BR. . Drug and Alcohol Dependence. August 2000, 60 (2): 133–40. PMID 10940540. doi:10.1016/S0376-8716(99)00152-0.
  7. Huffman JW, Liddle J, Yu S, Aung MM, Abood ME, Wiley JL, Martin BR. . Bioorganic & Medicinal Chemistry. December 1999, 7 (12): 2905–14. PMID 10658595. doi:10.1016/s0968-0896(99)00219-9.
  8. Huffman JW, Yu S, Showalter V, Abood ME, Wiley JL, Compton DR, Martin BR, Bramblett RD, Reggio PH. . Journal of Medicinal Chemistry. September 1996, 39 (20): 3875–7. PMID 8831752. doi:10.1021/JM960394Y.
  9. Bow EW, Rimoldi JM. The Structure-Function Relationships of Classical Cannabinoids: CB1/CB2 Modulation. Perspect Medicin Chem. 2016 Jun 28;8:17-39. doi:10.4137/PMC.S32171 PMID 27398024
  10. Huffman JW, Mabon R, Wu MJ, Lu J, Hart R, Hurst DP, Reggio PH, Wiley JL, Martin BR. . Bioorganic & Medicinal Chemistry. February 2003, 11 (4): 539–49. PMID 12538019. S2CID 29107765. doi:10.1016/S0968-0896(02)00451-0.
  11. Martin BR, Jefferson R, Winckler R, Wiley JL, Huffman JW, Crocker PJ, Saha B, Razdan RK. Manipulation of the tetrahydrocannabinol side chain delineates agonists, partial agonists, and antagonists. J Pharmacol Exp Ther. 1999 Sep;290(3):1065-79. PMID 10454479
  12. Howlett AC, Barth F, Bonner TI, Cabral G, Casellas P, Devane WA, Felder CC, Herkenham M, Mackie K, Martin BR, Mechoulam R, Pertwee RG. . Pharmacological Reviews. June 2002, 54 (2): 161–202. PMID 12037135. S2CID 8259002. doi:10.1124/pr.54.2.161.
  13. Huffman JW, Padgett LW, Isherwood ML, Wiley JL, Martin BR. . Bioorganic & Medicinal Chemistry Letters. October 2006, 16 (20): 5432–5. PMID 16889960. doi:10.1016/j.bmcl.2006.07.051.
  14. Marriott KS, Huffman JW. . Current Topics in Medicinal Chemistry. 2008, 8 (3): 187–204. PMID 18289088. doi:10.2174/156802608783498014.
  15. Huffman JW, Szklennik PV, Almond A, Bushell K, Selley DE, He H, Cassidy MP, Wiley JL, Martin BR. . Bioorganic & Medicinal Chemistry Letters. September 2005, 15 (18): 4110–3. PMID 16005223. doi:10.1016/j.bmcl.2005.06.008.
  16. Huffman JW, Bushell SM, Miller JR, Wiley JL, Martin BR. . Bioorganic & Medicinal Chemistry. December 2002, 10 (12): 4119–29. PMID 12413866. doi:10.1016/s0968-0896(02)00331-0.
  17. Wiley JL, Smith VJ, Chen J, Martin BR, Huffman JW. . Bioorganic & Medicinal Chemistry. 2012, 20 (6): 2067–2081. PMC 3298571 可免费查阅. PMID 22341572. doi:10.1016/j.bmc.2012.01.038.
  18. . The Receptors. 2009. ISBN 978-1-58829-712-9. doi:10.1007/978-1-59745-503-9.
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