FOXP3

FOXP3
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	3QRF、4WK8
識別號
别名	FOXP3；, AIID, DIETER, IPEX, JM2, PIDX, XPID, forkhead box P3
外部ID	OMIM：300292 MGI：1891436 HomoloGene：8516 GeneCards：FOXP3
相關疾病
	IPEX症候群[1]
基因位置（人类）
染色体	X染色體[2]
终止	49,270,477 bp[2]
基因位置（小鼠）
染色体	小鼠X染色体[3]
终止	7,461,484 bp[3]
RNA表达模式
	; ;
	查阅更多表达数据
基因本體
分子功能	• sequence-specific DNA binding; • NF-kappaB binding; • transcription corepressor activity; • nucleic acid binding; • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; • 血浆蛋白结合; • histone deacetylase binding; • DNA结合转录因子活性; • NFAT protein binding; • histone acetyltransferase binding; • 金屬離子結合; • DNA结合; • protein homodimerization activity; • DNA-binding transcription factor activity, RNA polymerase II-specific; • RNA polymerase II cis-regulatory region sequence-specific DNA binding;
細胞組分	• 细胞核; • 胞內; • 細胞質; • 核质; • 大分子复合体;
生物學過程	• negative regulation of cell population proliferation; • negative regulation of NF-kappaB transcription factor activity; • B cell homeostasis; • regulation of isotype switching to IgG isotypes; • myeloid cell homeostasis; • negative regulation of inflammatory response; • positive regulation of interleukin-4 production; • regulation of immunoglobulin production; • regulation of transcription by RNA polymerase II; • regulation of T cell anergy; • negative regulation of interleukin-6 production; • tolerance induction to self antigen; • regulation of transcription, DNA-templated; • negative regulation of DNA-binding transcription factor activity; • positive regulation of T cell tolerance induction; • negative regulation of immune response; • negative regulation of interferon-gamma production; • tolerance induction; • regulatory T cell differentiation; • positive regulation of transcription, DNA-templated; • negative regulation of interleukin-2 production; • positive regulation of histone acetylation; • negative regulation of interleukin-5 production; • negative regulation of chronic inflammatory response; • CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; • positive regulation of transcription by RNA polymerase II; • negative regulation of activated T cell proliferation; • positive regulation of gene expression; • negative regulation of interleukin-4 production; • negative regulation of interleukin-10 production; • 腫瘤壞死因子產生的負調控; • T cell homeostasis; • negative regulation of CREB transcription factor activity; • negative regulation of T-helper 17 cell differentiation; • T细胞活化; • positive regulation of immature T cell proliferation in thymus; • positive regulation of regulatory T cell differentiation; • negative regulation of transcription by RNA polymerase II; • positive regulation of peripheral T cell tolerance induction; • positive regulation of transforming growth factor beta1 production; • negative regulation of transcription, DNA-templated; • negative regulation of lymphocyte proliferation; • negative regulation of histone acetylation; • negative regulation of interleukin-17 production; • response to virus; • negative regulation of histone deacetylation; • CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment; • positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; • negative regulation of T cell proliferation; • 染色体重建; • cytokine production; • negative regulation of T cell cytokine production; • negative regulation of isotype switching to IgE isotypes; • T cell receptor signaling pathway; • positive regulation of T cell anergy; • transcription, DNA-templated; • T cell mediated immunity; • negative regulation of gene expression; • anatomical structure morphogenesis; • regulation of Wnt signaling pathway; • regulation of regulatory T cell differentiation;
	Sources:Amigo / QuickGO
直系同源
	50943
	20371
	ENSG00000049768
	ENSMUSG00000039521
	Q9BZS1
	Q99JB6
	NM_001114377; NM_014009
	NM_001199347; NM_001199348; NM_054039
	NP_001107849; NP_054728
	NP_001186276; NP_001186277; NP_473380
	維基數據

FOXP3（Forkhead box protein P3）基因，即叉头框P3基因，也称为scurfin蛋白，位于X染色体，属于FOX蛋白家族，是一种与免疫系统响应有关的转录因子[6]。

参考文献

.
GRCh38: Ensembl release 89: ENSG00000049768 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000039521 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
Brunkow ME, Jeffery EW, Hjerrild KA, Paeper B, Clark LB, Yasayko SA, Wilkinson JE, Galas D, Ziegler SF, Ramsdell F. . Nature Genetics. January 2001, 27 (1): 68–73. PMID 11138001. S2CID 13389419. doi:10.1038/83784.

外部链接

GeneReviews/NIH/NCBI/UW entry on IPEX Syndrome （页面存档备份，存于）
醫學主題詞表（MeSH）：FOXP3+protein,+human

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[1] .

[refGRCh38Ensembl-2] GRCh38: Ensembl release 89: ENSG00000049768 - Ensembl, May 2017

[refGRCm38Ensembl-3] GRCm38: Ensembl release 89: ENSMUSG00000039521 - Ensembl, May 2017

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[Brunkow_2001-6] Brunkow ME, Jeffery EW, Hjerrild KA, Paeper B, Clark LB, Yasayko SA, Wilkinson JE, Galas D, Ziegler SF, Ramsdell F. . Nature Genetics. January 2001, 27 (1): 68–73. PMID 11138001. S2CID 13389419. doi:10.1038/83784.