EGLU

EGLU（全称(2S)-α-乙基谷氨酸，英語：）是一种含氮有机化合物，分子式C7H13NO4，是首个发现的II型代谢型谷氨酸受体（mGluR2/3）的选择性拮抗剂。[1][2][3][4][5][6][7]

EGLU
识别
  • (2S)-2-Amino-2-ethylpentanedioic acid
CAS号170984-72-2  checkY[yes]
PubChem CID
IUPHAR/BPS
ChemSpider
CompTox Dashboard (EPA)
化学
化学式C7H13NO4
摩尔质量175.18 g·mol−1
3D模型（JSmol）
  • O=C(O)CC[C@](N)(C(=O)O)CC
  • InChI=1S/C7H13NO4/c1-2-7(8,6(11)12)4-3-5(9)10/h2-4,8H2,1H3,(H,9,10)(H,11,12)/t7-/m0/s1 ☒N
  • Key:QFYBYZLHPIALCZ-ZETCQYMHSA-N ☒N

参考文献
  1. Jane DE, Thomas NK, Tse HW, Watkins JC. . Neuropharmacology. 1996, 35 (8): 1029–35. PMID 9121605. S2CID 6238847. doi:10.1016/S0028-3908(96)00048-2.
  2. Huang L, Rowan MJ, Anwyl R. . European Journal of Pharmacology. February 1999, 366 (2–3): 151–8. PMID 10082195. doi:10.1016/S0014-2999(98)00918-2.
  3. Palazzo E, Marabese I, de Novellis V, Oliva P, Rossi F, Berrino L, et al. . Neuropharmacology. March 2001, 40 (3): 319–26. PMID 11166324. S2CID 41189905. doi:10.1016/S0028-3908(00)00160-X.
  4. Iserhot C, Gebhardt C, Schmitz D, Heinemann U. . Brain Research. November 2004, 1027 (1–2): 151–60. PMID 15494166. S2CID 33373525. doi:10.1016/j.brainres.2004.08.052.
  5. Cahusac PM, Wan H. . Neuroscience. April 2007, 146 (1): 202–12. PMID 17346894. S2CID 37975672. doi:10.1016/j.neuroscience.2007.01.049.
  6. Kim WY, Vezina P, Kim JH. . Behavioural Brain Research. August 2008, 191 (1): 62–6. PMID 18433894. S2CID 24250755. doi:10.1016/j.bbr.2008.03.010.
  7. Altinbilek B, Manahan-Vaughan D. . Neuroscience. January 2009, 158 (1): 149–58. PMID 18722513. S2CID 40251815. doi:10.1016/j.neuroscience.2008.07.045.
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