CYP46A1

CYP46A1
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	4FIA、2Q9F、3MDV、4J14、4ENH、2Q9G、3MDM、3MDT、3MDR
識別號
别名	CYP46A1；, CP46, CYP46, cytochrome P450 family 46 subfamily A member 1
外部ID	OMIM：604087 MGI：1341877 HomoloGene：134501 GeneCards：CYP46A1
基因位置（人类）
染色体	14號染色體[1]
终止	99,727,301 bp[1]
基因位置（小鼠）
染色体	小鼠12号染色体[2]
终止	108,328,493 bp[2]
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• iron ion binding; • 金屬離子結合; • monooxygenase activity; • steroid hydroxylase activity; • heme binding; • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; • oxidoreductase activity; • cholesterol 24-hydroxylase activity;
細胞組分	• organelle membrane; • integral component of membrane; • endoplasmic reticulum membrane; • 膜; • 細胞內膜結合細胞器; • 内质网; • 树突; • presynapse; • postsynapse; • 细胞连接; • cell projection; • 突触;
生物學過程	• steroid metabolic process; • 脂質代謝; • cholesterol metabolic process; • cholesterol catabolic process; • 神經系統的發育; • sterol metabolic process; • bile acid biosynthetic process; • xenobiotic metabolic process; • progesterone metabolic process; • regulation of long-term synaptic potentiation; • C21-steroid hormone metabolic process;
	Sources:Amigo / QuickGO
直系同源
	10858
	13116
	ENSG00000036530
	ENSMUSG00000021259
	Q9Y6A2
	Q9WVK8
	NM_006668
	NM_010010
	NP_006659
	NP_034140
	維基數據

{{{Name}}}
	Structure of cholesterol-24 hydroxlase (CYP46A1) in Homo sapiens. Based on PyMOL rendering of PDB 2Q9F.
命名
系统命名
缩写
识别码
EC編號	1.14.13.98
数据库
IntEnz	IntEnz浏览
BRENDA	BRENDA入口
ExPASy	NiceZyme浏览
KEGG	KEGG入口
MetaCyc	代谢路径
PRIAM	概述
PDB	RCSB PDB PDBj PDBe PDBsum
搜索
PMC	相关文献
PubMed	相关文献

细胞色素 P450 46A1（英語：，缩写CYP46A1）也被称为胆固醇24-羟化酶（，EC 1.14.13.98），是细胞色素P450超家族的一员，由CYP46A1基因编码，是催化胆固醇生成羟基化生成脑甾醇（24S-羟基胆固醇）的酶[5]。

参考文献

GRCh38: Ensembl release 89: ENSG00000036530 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000021259 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
Russell DW; Halford RW; Ramirez DMO; Shah R; Kotti T. . Annual Review of Biochemistry. 2009, 78: 1017–1040. PMC 2837268 . PMID 19489738. doi:10.1146/annurev.biochem.78.072407.103859.

外部链接

GeneReviews/NCBI/NIH/UW entry on Cerebrotendinous Xanthomatosis（页面存档备份，存于）
醫學主題詞表（MeSH）：Cytochrome+P-450+CYP27A1
Human CYP27A1 genome location and CYP27A1 gene details page in the UCSC Genome Browser.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000036530 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021259 - Ensembl, May 2017

[3] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[russell2009-5] Russell DW; Halford RW; Ramirez DMO; Shah R; Kotti T. . Annual Review of Biochemistry. 2009, 78: 1017–1040. PMC 2837268 . PMID 19489738. doi:10.1146/annurev.biochem.78.072407.103859.