CXCR5

Chemokine (C-X-C motif) receptor 5; 趋化因子（C-X-C基序）受体5
标识
代号	CXCR5; BLR1; CD185; MDR15
扩展标识	遗传学：601613 鼠基因：103567 同源基因：1298 IUPHAR: CXCR5 ChEMBL: 1075315 GeneCards: CXCR5 Gene
基因本体论描述
分子功能	· G-protein coupled receptor activity; · protein binding; · C-X-C chemokine receptor activity;
细胞成分	· plasma membrane; · integral component of plasma membrane;
生物过程	· cellular component movement; · chemotaxis; · immune response; · G-protein coupled receptor signaling pathway; · positive regulation of cytokinesis; · B cell activation; · lymph node development; · chemokine-mediated signaling pathway;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体

C-X-C趋化因子受体5（英語：，CXC-R5）也被称为CD185（分化簇185）或伯基特淋巴瘤受体1（英語：，BLR1）是一种G蛋白偶联的七跨膜受体，属于CXC趋化因子受体家族，其配体为趋化因子CXCL13（也被称为BLC）。在人类中，CXC-R5蛋白质由 CXCR5 基因编码[1]。

组织分布与功能

BLR1 / CXCR5 基因特异性表达于伯基特淋巴瘤以及其它淋巴组织，比如淋巴结和脾脏中的淋巴滤泡。该基因对B细胞的迁移起到重要作用[2]。

临床意义

T细胞会表达CD4⁺CXCR5⁺以对抗结核杆菌（Mtb）感染[3]。

参考文献

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延伸阅读

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[pmid1425907-1] Dobner T, Wolf I, Emrich T, Lipp M. . Eur. J. Immunol. November 1992, 22 (11): 2795–9. PMID 1425907. doi:10.1002/eji.1830221107.

[pmid8978608-2] Förster R, Mattis AE, Kremmer E, Wolf E, Brem G, Lipp M. . Cell. 1996, 87 (6): 1037–47. PMID 8978608. doi:10.1016/S0092-8674(00)81798-5.

[pmid23281399-3] Slight SR, Rangel-Moreno J, Gopal R, Lin Y, Fallert Junecko BA, Mehra S, Selman M, Becerril-Villanueva E, Baquera-Heredia J, Pavon L, Kaushal D, Reinhart TA, Randall TD, Khader SA. . J. Clin. Invest. January 2013. PMC 3561804 . PMID 23281399. doi:10.1172/JCI65728.