7α-羟基DHEA

7α-羟基DHEA英語:或7α-OH-DHEA,全称7α-羟基脱氢表雄酮,7α-Hydroxydehydroepiandrosterone,也称为3β,7α-二羟基雄-5-烯-17-酮,3β,7α-dihydroxyandrost-5-ene-17-one)是一种内源性的天然雄激素,是脱氢表雄酮的主要代谢产物之一(另一种是7β-羟基DHEA),这一反应在前列腺CYP7B1催化,在肝脏CYP3A4催化[1][2]

7α-羟基DHEA
IUPAC名
(3aS,3bR,4S,7S,9aR,9bS,11aS)-4,7-Dihydroxy-9a,11a-dimethyl-2,3,3a,3b,4,6,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[a]phenanthren-1-one
别名 7α-OH-DHEA; 3β,7α-Dihydroxyandrost-5-ene-17-one; Androst-5-en-3β,7α-diol-17-one
识别
CAS号 53-00-9
PubChem 65517
ChemSpider 58963
SMILES
 
  • C[C@]12CC[C@H]3[C@H]([C@@H]1CCC2=O)[C@@H](C=C4[C@@]3(CC[C@@H](C4)O)C)O
ChEBI 81471
KEGG C18045
性质
化学式 C19H28O3
摩尔质量 304.42 g·mol−1
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

参考文献

  1. . Human Metabolome Database. [2022-02-07]. (原始内容存档于2017-10-18).
  2. Miller KK, Al-Rayyan N, Ivanova MM, Mattingly KA, Ripp SL, Klinge CM, Prough RA. . Steroids. 2013, 78 (1): 15–25. PMC 3529809可免费查阅. PMID 23123738. doi:10.1016/j.steroids.2012.10.002.
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