7α-羟基胆固醇

7α-羟基胆固醇（英語：）是动物体内合成胆汁酸的前体，由胆固醇7α-羟化酶（CYP7A1）催化，是胆汁酸合成的限速步驟[2]。

7α-Hydroxycholesterol
IUPAC名
(3S,7S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol
识别
CAS号 566-26-7  checkY
PubChem 107722
ChemSpider 96891
SMILES
 
  • CC(C)CCC[C@@H](C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2[C@@H](C=C4[C@@]3(CC[C@@H](C4)O)C)O)C
InChI
 
  • 1/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h16-18,20-25,28-29H,6-15H2,1-5H3/t18-,20+,21-,22+,23+,24-,25+,26+,27-/m1/s1
InChIKey OYXZMSRRJOYLLO-RVOWOUOIBF
MeSH 7+alpha-hydroxycholesterol
IUPHAR配体 4351
性质
化学式 C27H46O2
402.653 g/mol g·mol⁻¹
熔点 174—176 °C（447—449 K）[1]
若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

参考文献
  1. >Haslewood, G. A. D. . Biochemical Journal. 1941, 35 (5-6): 708–711. ISSN 0306-3283. doi:10.1042/bj0350708.
  2. Miao J. (学位论文). University of Illinois at Urbana-Champaign. 2008.


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