20-羟基蜕皮酮

20-羟基蜕皮酮或写为20-羟基蜕皮甾酮英語:或ecdysterone,缩写20E)是一种天然的蜕皮激素,参与节肢动物特别是昆虫蜕皮变态发育。昆虫体内的20-羟基蜕皮酮由万圣节基因CYP314a1氧化蜕皮酮(ecdysone)第20号碳原子的β位而来[1],作用于蜕皮激素受体。此外,植物蜕皮类固醇也包括20-羟基蜕皮酮[2]

20-羟基蜕皮酮
Skeletal formula of 20-hydroxyecdysone
Ball-and-stick model of the 20-hydroxyecdysone molecule
臨床資料
懷孕分級
  • X
给药途径Oral
法律規範狀態
法律規範
  • Undetermined
藥物動力學數據
药物代谢Hepatic
生物半衰期4-9 hours
排泄途徑Urinary:?%
识别
  • (2β,3β,5β,22R)-2,3,14,20,22,25-Hexahydroxycholest-7-en-6-one
CAS号5289-74-7  ☒N
PubChem CID
ChemSpider
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.241.312
化学
化学式C27H44O7
摩尔质量480.63 g/mol
3D模型(JSmol
  • O=C1\C=C3/[C@@H]([C@]2(C[C@H](O)[C@H](O)C[C@@H]12)C)CC[C@]4([C@@]3(O)CC[C@@H]4[C@](O)(C)[C@H](O)CCC(O)(C)C)C
  • InChI=1S/C27H44O7/c1-23(2,32)9-8-22(31)26(5,33)21-7-11-27(34)16-12-18(28)17-13-19(29)20(30)14-24(17,3)15(16)6-10-25(21,27)4/h12,15,17,19-22,29-34H,6-11,13-14H2,1-5H3/t15-,17-,19+,20-,21-,22+,24+,25+,26+,27+/m0/s1 checkY
  • Key:NKDFYOWSKOHCCO-YPVLXUMRSA-N checkY

参考文献

  1. . The Journal of Steroid Biochemistry and Molecular Biology. 2011-11-01, 127 (3-5): 196–203 [2019-06-23]. ISSN 0960-0760. doi:10.1016/j.jsbmb.2010.09.001. (原始内容存档于2019-08-21) (英语).
  2. Dinan L, Savchenko T, Whiting P. . Cellular and Molecular Life Sciences. 2001, 58 (8): 1121–1132. PMID 11529504. doi:10.1007/PL00000926.
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