鲨烯-藿烯环化酶

Squalene-hopene cyclase
	鲨烯-藿烯环化酶二聚体的晶体结构
命名
系统命名
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识别码
EC編號	or 4/2/1/129.html 5.4.99.17
CAS号	76600-69-6
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IntEnz	IntEnz浏览
BRENDA	BRENDA入口
ExPASy	NiceZyme浏览
KEGG	KEGG入口
MetaCyc	代谢路径
PRIAM	概述
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鲨烯-藿烯环化酶（英語：，缩写SHC，EC 5.4.99.17）或称作藿烷-22-醇水裂解酶（hopan-22-ol hydro-lyase，EC 4.2.1.129）属于原核生物中生成五环三萜的环化/变位酶家族，能催化下列两种反应，生成藿烯或藿烷-22-醇，两种产物的比例为5比1[1][2][3][4][5]：

鲨烯

\rightleftharpoons

22(29)-藿烯

鲨烯 + H₂O

\rightleftharpoons

藿烷-22-醇

参考文献

Hoshino T, Sato T. . Chemical Communications. February 2002, (4): 291–301. PMID 12120044. doi:10.1039/b108995c.
Hoshino T, Nakano S, Kondo T, Sato T, Miyoshi A. . Organic & Biomolecular Chemistry. May 2004, 2 (10): 1456–70. PMID 15136801. doi:10.1039/b401172d.
Sato T, Kouda M, Hoshino T. . Bioscience, Biotechnology, and Biochemistry. March 2004, 68 (3): 728–38. PMID 15056909. doi:10.1271/bbb.68.728.
Reinert DJ, Balliano G, Schulz GE. . Chemistry & Biology. January 2004, 11 (1): 121–6. PMID 15113001. doi:10.1016/j.chembiol.2003.12.013.
Pearson A, Budin M, Brocks JJ. . Proceedings of the National Academy of Sciences of the United States of America. December 2003, 100 (26): 15352–7. PMC 307571 . PMID 14660793. doi:10.1073/pnas.2536559100.

外部链接

醫學主題詞表（MeSH）：Squalene-hopene+cyclase

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[1] Hoshino T, Sato T. . Chemical Communications. February 2002, (4): 291–301. PMID 12120044. doi:10.1039/b108995c.

[2] Hoshino T, Nakano S, Kondo T, Sato T, Miyoshi A. . Organic & Biomolecular Chemistry. May 2004, 2 (10): 1456–70. PMID 15136801. doi:10.1039/b401172d.

[3] Sato T, Kouda M, Hoshino T. . Bioscience, Biotechnology, and Biochemistry. March 2004, 68 (3): 728–38. PMID 15056909. doi:10.1271/bbb.68.728.

[Reinert,_D.J.,_Balliano,_G._and_Schulz,_G.E._2004_121–126-4] Reinert DJ, Balliano G, Schulz GE. . Chemistry & Biology. January 2004, 11 (1): 121–6. PMID 15113001. doi:10.1016/j.chembiol.2003.12.013.

[Pearson,_A.,_Budin,_M.,_and_Brocks,_J._2003_15352–15357-5] Pearson A, Budin M, Brocks JJ. . Proceedings of the National Academy of Sciences of the United States of America. December 2003, 100 (26): 15352–7. PMC 307571 . PMID 14660793. doi:10.1073/pnas.2536559100.