腺苷A_2A受體

腺苷A2A受體
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	2YDO、2YDV、3EML、3PWH、3QAK、3REY、3RFM、3UZA、3UZC、3VG9、3VGA、4EIY、4UG2、4UHR、5IU4、5IU7、5IUA、5IU8、5IUB
識別號
别名	ADORA2A；, adenosine A2a receptor, A2aR, ADORA2, RDC8
外部ID	OMIM：102776 MGI：99402 HomoloGene：20166 GeneCards：ADORA2A
為以下藥物的標靶
	腺苷、BAY 60-6583、Regadenoson、UK-432,097、CCPA、CGS-21680、cyclopentyladenosine、咖啡因、CGS 15943、8-环戊基-1,3-二丙基黄嘌呤、flavone、高良姜素、istradefylline、桑色素、瑞德南特、rolofylline、sakuranetin、sch-442416、sch-58261、茶碱、ZM-241385[1]
基因位置（人类）
染色体	22號染色體[2]
终止	24,442,357 bp[2]
基因位置（小鼠）
染色体	小鼠10号染色体[3]
终止	75,170,618 bp[3]
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• G protein-coupled adenosine receptor activity; • G protein-coupled receptor activity; • signal transducer activity; • 血浆蛋白结合; • 相同蛋白质结合; • 酶结合; • alpha-actinin binding; • type 5 metabotropic glutamate receptor binding; • protein heterodimerization activity;
細胞組分	• integral component of membrane; • 膜; • 细胞膜; • integral component of plasma membrane; • 中间纤维; • 內膜系統; • 突触后致密物质; • 轴突; • 树突; • axolemma; • asymmetric synapse; • presynaptic membrane; • neuronal cell body; • postsynaptic membrane; • presynaptic active zone; • integral component of postsynaptic membrane; • integral component of presynaptic membrane; • glutamatergic synapse; • Golgi membrane;
生物學過程	• cAMP biosynthetic process; • G protein-coupled adenosine receptor signaling pathway; • sensory perception; • adenylate cyclase-modulating G protein-coupled receptor signaling pathway; • cell-cell signaling; • 凝血; • blood circulation; • cellular defense response; • central nervous system development; • 吞噬作用; • inflammatory response; • 訊息傳遞; • 细胞凋亡; • synaptic transmission, dopaminergic; • response to amphetamine; • regulation of transcription, DNA-templated; • negative regulation of protein kinase activity; • protein kinase C-activating G protein-coupled receptor signaling pathway; • synaptic transmission, cholinergic; • locomotory behavior; • negative regulation of cell population proliferation; • positive regulation of glutamate secretion; • positive regulation of acetylcholine secretion, neurotransmission; • regulation of norepinephrine secretion; • response to caffeine; • positive regulation of synaptic transmission, GABAergic; • synaptic transmission, glutamatergic; • positive regulation of urine volume; • positive regulation of renal sodium excretion; • negative regulation of locomotion; • 血管舒張; • eating behavior; • negative regulation of vascular permeability; • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; • response to alkaloid; • negative regulation of neuron apoptotic process; • positive regulation of circadian sleep/wake cycle, sleep; • negative regulation of alpha-beta T cell activation; • astrocyte activation; • neuron projection morphogenesis; • positive regulation of protein secretion; • negative regulation of inflammatory response; • regulation of mitochondrial membrane potential; • membrane depolarization; • regulation of calcium ion transport; • positive regulation of synaptic transmission, glutamatergic; • 興奮性動作電位; • 抑制性突觸; • 前脉冲抑制; • positive regulation of apoptotic signaling pathway; • G protein-coupled receptor signaling pathway; • adenylate cyclase-activating G protein-coupled receptor signaling pathway; • positive regulation of long-term synaptic potentiation; • regulation of synaptic vesicle exocytosis;
	Sources:Amigo / QuickGO
直系同源
	135
	11540
	ENSG00000128271
	ENSMUSG00000020178
	P29274
	Q60613
	NM_000675; NM_001278497; NM_001278498; NM_001278499; NM_001278500
	NM_009630; NM_001331095; NM_001331096
	NP_000666; NP_001265426; NP_001265427; NP_001265428; NP_001265429
	NP_001318024; NP_001318025; NP_033760
	維基數據

腺苷A_2A受體(adenosine A_2A receptor)，也稱為ADORA2A，是一種腺苷受體，也表示編碼它的人類基因。[6][7]

參考資料

.
GRCh38: Ensembl release 89: ENSG00000128271 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000020178 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
Libert F, Parmentier M, Lefort A, Dinsart C, Van Sande J, Maenhaut C, et al. . Science. May 1989, 244 (4904): 569–72. Bibcode:1989Sci...244..569L. PMID 2541503. doi:10.1126/science.2541503.
Libert F, Passage E, Parmentier M, Simons MJ, Vassart G, Mattei MG. . Genomics. September 1991, 11 (1): 225–7. PMID 1662665. doi:10.1016/0888-7543(91)90125-X.

深入閱讀

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外部連結

Human ADORA2A genome location and ADORA2A gene details page in the UCSC Genome Browser.

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[1] .

[refGRCh38Ensembl-2] GRCh38: Ensembl release 89: ENSG00000128271 - Ensembl, May 2017

[refGRCm38Ensembl-3] GRCm38: Ensembl release 89: ENSMUSG00000020178 - Ensembl, May 2017

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2541503-6] Libert F, Parmentier M, Lefort A, Dinsart C, Van Sande J, Maenhaut C, et al. . Science. May 1989, 244 (4904): 569–72. Bibcode:1989Sci...244..569L. PMID 2541503. doi:10.1126/science.2541503.

[pmid1662665-7] Libert F, Passage E, Parmentier M, Simons MJ, Vassart G, Mattei MG. . Genomics. September 1991, 11 (1): 225–7. PMID 1662665. doi:10.1016/0888-7543(91)90125-X.

腺苷A2A受體

參考資料

深入閱讀

外部連結

腺苷A_2A受體