甘珀酸

甘珀酸（英語：，缩写CBX）是一种甾体激素类似物，为甘草次酸与丁二酸在3β羟基位置形成的酯，和光果甘草根部中提取的甘草酸结构上类似[1]。

甘珀酸
Skeletal formula of carbenoxolone
Ball-and-stick model of the carbenoxolone molecule
臨床資料
AHFS/Drugs.com国际药品名称
ATC碼
识别
  • (3β)-3-[(3-carboxypropanoyl)oxy]-11-oxoolean-12-en-30-oic acid
    OR
    (2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-(3-carboxypropanoyloxy)-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid
CAS号5697-56-3  ☒N
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.024.704
化学
化学式C34H50O7
摩尔质量570.765 g/mol
3D模型（JSmol）
  • O=C(O)CCC(=O)O[C@H]4CC[C@@]3([C@H]5C(=O)/C=C2/[C@@H]1C[C@](C(=O)O)(C)CC[C@]1(C)CC[C@]2([C@@]5(CC[C@H]3C4(C)C)C)C)C
  • InChI=1S/C34H50O7/c1-29(2)23-10-13-34(7)27(32(23,5)12-11-24(29)41-26(38)9-8-25(36)37)22(35)18-20-21-19-31(4,28(39)40)15-14-30(21,3)16-17-33(20,34)6/h18,21,23-24,27H,8-17,19H2,1-7H3,(H,36,37)(H,39,40)/t21-,23-,24-,27+,30+,31-,32-,33+,34+/m0/s1 checkY
  • Key:OBZHEBDUNPOCJG-WBXJDKIVSA-N checkY

甘珀酸可抑制11β-羟基类固醇脱氢酶（11β-HSD）将可的松转化为皮質醇[2][3]。

另见

参考文献
  1. Connors BW. . Epilepsy Curr. 2012, 12 (2): 66–8. PMC 3316363 可免费查阅. PMID 22473546. doi:10.5698/1535-7511-12.2.66.
  2. . （原始内容存档于2017-05-11）.
  3. (PDF). （原始内容存档 (PDF)于2016-03-06）.


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