氢吗啡酮

氢吗啡酮英語:,也称为二氢吗啡酮,dihydromorphinone,商品名:Dilaudid)是一种含氮有机化合物,化学式C17H19NO3,是一种用于缓解中度至重度疼痛吗啡喃類阿片药物[5]

氢吗啡酮
Structural formula of hydromorphone
Space-filling model of hydromorphone
臨床資料
商品名Dilaudid, Palladone, others
其他名稱Dihydromorphinone
AHFS/Drugs.comMonograph
MedlinePlusa682013
核准狀況
懷孕分級
依賴性High[2]
成癮性High[3]
给药途径By mouth, intramuscular, intravenous, subcutaneous
藥物類別Opioid
ATC碼
法律規範狀態
法律規範
藥物動力學數據
生物利用度By mouth: 30–35%, Intranasal: 52–58%,[4] IV/IM: 100%
血漿蛋白結合率20%
药物代谢
藥效起始時間15-30分钟[5]
生物半衰期2–3 hours[6]
作用時間4 to 5 hrs[5]
排泄途徑Kidney
识别
  • 4,5-α-Epoxy-3-hydroxy-17-methyl morphinan-6-one
CAS号466-99-9  checkY
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.006.713
化学
化学式C17H19NO3
摩尔质量285.34 g·mol−1
3D模型(JSmol
水溶性HCl salt: 333
  • O=C4[C@@H]5Oc1c2c(ccc1O)C[C@H]3N(CC[C@]25[C@H]3CC4)C
  • InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2,4,10-11,16,19H,3,5-8H2,1H3/t10-,11+,16-,17-/m0/s1 checkY
  • Key:WVLOADHCBXTIJK-YNHQPCIGSA-N checkY

参考文献

  1. . Drugs.com. 19 November 2019 [16 May 2020].
  2. Bonewit-West K, Hunt SA, Applegate E. . Elsevier Health Sciences. 2012: 571. ISBN 9781455701506 (英语).
  3. Bonewit-West K, Hunt SA, Applegate E. . Elsevier Health Sciences. 2012: 571 [20 August 2019]. ISBN 9781455701506. (原始内容存档于10 January 2023).
  4. Coda BA, Rudy AC, Archer SM, Wermeling DP. . Anesthesia and Analgesia. July 2003, 97 (1): 117–23, table of contents. CiteSeerX 10.1.1.551.6509可免费查阅. PMID 12818953. S2CID 22694749. doi:10.1213/01.ANE.0000066311.40978.4F.
  5. . Drugs.com. American Society of Health-System Pharmacists. [15 April 2019] (英语).
  6. Vallner JJ, Stewart JT, Kotzan JA, Kirsten EB, Honigberg IL. . Journal of Clinical Pharmacology. April 1981, 21 (4): 152–156. PMID 6165742. S2CID 29864565. doi:10.1002/j.1552-4604.1981.tb05693.x.

外部链接

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