异孕烷醇酮

异孕烷醇酮英語:),也被称为异别孕烷醇酮(isoallopregnanolone),或表别孕烷醇酮(epiallopregnanolone), 3β-羟基-5α-孕烷-20-酮,3β-hydroxy-5α-pregnan-20-one,或3β,5α-四氢孕酮,3β,5α-tetrahydroprogesterone(3β,5α-THP)是一种内源神经甾体别孕烷醇酮天然3β-差向异构体[1][2]

异孕烷醇酮
IUPAC名
3β-Hydroxy-5α-pregnan-20-one
别名 Isoallopregnanolone; Epiallopregnanolone; Sepranolone; 3β,5α-Tetrahydroprogesterone; 3β,5α-THP
识别
CAS号 516-55-2
PubChem 92787
ChemSpider 83761
SMILES
 
  • CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC[C@@H]4[C@@]3(CC[C@@H](C4)O)C)C
InChI
 
  • 1/C21H34O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14-19,23H,4-12H2,1-3H3/t14-,15-,16-,17+,18-,19-,20-,21+/m0/s1
InChIKey AURFZBICLPNKBZ-FZCSVUEKBS
性质
化学式 C21H34O2
318.49 g/mol g·mol¹
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

另见

参考文献

  1. Hedström H, Bixo M, Nyberg S, Spigset O, Zingmark E, Bäckström T. . Psychopharmacology. 2009, 203 (1): 85–98. PMID 18949461. doi:10.1007/s00213-008-1372-8.
  2. Öfverman, C., Strömberg, J., Birzniece, V., Turkmen, S., Hill, M., Lundgren, P., ... & Johansson, I. M. (2009). The progesterone metabolite isoallopregnanolone is a subunit-selective antagonist of the GABA-A receptor. Chicago

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