奥贝胆酸

**奥贝胆酸**
臨床資料
商品名	Ocaliva
其他名稱	6α-ethyl-chenodeoxycholic acid; INT-747
AHFS/Drugs.com	ocaliva
MedlinePlus	a616033
核准狀況	歐 EMA: yes;
给药途径	口服给药
ATC碼	A05AA04 (WHO) ;
法律規範狀態
法律規範	美：处方药（℞-only）;
识别
	IUPAC命名法 (3α,5β,6α,7α)-6-Ethyl-3,7-dihydroxycholan-24-oic acid OR (4R)-4-[(3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid; ;
CAS号	459789-99-2
PubChem CID	447715;
IUPHAR/BPS	3435;
ChemSpider	394730;
UNII	0462Z4S4OZ;
KEGG	D09360;
ChEBI	CHEBI:43602 ;
ChEMBL	ChEMBL566315;
CompTox Dashboard (EPA)	DTXSID20196671 ;
ECHA InfoCard	100.238.318
化学
化学式	C26H44O4
摩尔质量	420.62516 g/mol
3D模型（JSmol）	交互式图像;
熔点	108—110 °C（226—230 °F） [1]
	SMILES CC[C@@H]1[C@@H]2C[C@@H](CC[C@@]2([C@H]3CC[C@]4([C@H]([C@@H]3[C@@H]1O)CC[C@@H]4[C@H](C)CCC(=O)O)C)C)O;
	InChI InChI=1S/C26H44O4/c1-5-17-21-14-16(27)10-12-26(21,4)20-11-13-25(3)18(15(2)6-9-22(28)29)7-8-19(25)23(20)24(17)30/h15-21,23-24,27,30H,5-14H2,1-4H3,(H,28,29)/t15-,16-,17-,18-,19+,20+,21+,23+,24-,25-,26-/m1/s1; Key:ZXERDUOLZKYMJM-ZWECCWDJSA-N;

奥贝胆酸（英語：，缩写OCA，也叫做6α-乙基-鹅去氧胆酸，6α-ethyl-chenodeoxycholic acid，商品名Ocaliva）是一种半合成胆汁酸，用于治疗原发性胆汁性胆管炎，后又用于治疗几种肝病。大日本住友製藥拥有此药在中国和日本的所有权[2]。

参考文献

Gioiello, Antimo; Macchiarulo, Antonio; Carotti, Andrea; Filipponi, Paolo; Costantino, Gabriele; Rizzo, Giovanni; Adorini, Luciano; Pellicciari, Roberto. . Bioorganic & Medicinal Chemistry. April 2011, 19 (8): 2650–2658. PMID 21459580. doi:10.1016/j.bmc.2011.03.004.
Wall Street Journal. . [10 January 2014]. （原始内容存档于2014-03-28）.

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