乙米韦林

乙米韦林INN:Emivirine;开发代号:MKC-442)是一种治疗HIV的实验性药物,但研发失败了。它是一种非核苷类逆转录酶抑制剂[1]虽然乙米韦林在体外显示积极的抗病毒活性,但在人体试验中未能显示出足够的功效。然而,它作为一个早期的概念证明仍然值得注意,它导致了许多相关抗病毒药物的发现。[2]

乙米韦林
IUPAC名
6-Benzyl-1-(ethoxymethyl)-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione
识别
CAS号 149950-60-7  checkY
PubChem 65013
ChemSpider 58529
SMILES
 
  • CCOCN1C(=C(C(=O)NC1=O)C(C)C)CC2=CC=CC=C2
InChI
 
  • 1/C17H22N2O3/c1-4-22-11-19-14(10-13-8-6-5-7-9-13)15(12(2)3)16(20)18-17(19)21/h5-9,12H,4,10-11H2,1-3H3,(H,18,20,21)
InChIKey MLILORUFDVLTSP-UHFFFAOYAG
性质
化学式 C17H22N2O3
302.36818 g/mol g·mol¹
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

参考资料

  1. .
  2. Calenbergh SV, Herdewijn P. A heterogeneous collection of novel antiviral pyrimidines. Expert Opinion on Therapeutic Patents 2000; 10(3):289-295. DOI:10.1517/13543776.10.3.289
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